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Inhibition of human placental microsomal fraction 17beta-HS2 using [3H]-E2 as substrate in presence of NAD+ measured after 10 mins by HPLC method
Assay data:14 Active, 4 Activity ≤ 1 µM, 19 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of human placental microsomal fraction 17beta-HSD2 using [3H]-E2 as substrate in presence of NAD+ measured after 20 mins by HPLC method
Assay data:10 Active, 6 Activity ≤ 1 µM, 10 Tested
Inhibition of HSD17B2 (unknown origin) using estradiol as substrate incubated for 45 mins and measured after 1 hr by NADH Glo luminescence assay
Assay data:19 Active, 113 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Radioactivity Assay from US Patent US8546392: "17Beta-hydroxysteroid dehydrogenase type 1 inhibitors for the treatment of hormone-related diseases"
Assay data:17 Active, 17 Activity ≤ 1 µM, 17 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Inhibition of 17beta-HSD2 from Article 10.1021/jm8006917: "Design, synthesis, biological evaluation and pharmacokinetics of bis(hydroxyphenyl) substituted azoles, thiophenes, benzenes, and aza-benzenes as potent and selective nonsteroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1)."
Assay data:16 Active, 3 Activity ≤ 1 µM, 16 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Inhibition of 17beta-HSD2 in human using MDA-MB-231 cells using [3H]-E2 as substrate after 6 hrs by cell-based assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of human placental microsomal fraction 17beta-HSD2 using [3H]-E2 as substrate in presence of NAD+ by radio-HPLC analysis
Assay data:16 Active, 5 Activity ≤ 1 nM, 16 Activity ≤ 1 µM, 16 Tested
Assay data:15 Active, 15 Activity ≤ 1 µM, 15 Tested
Inhibition of human placental microsomal fraction 17beta-HSD2 at 10 nM using [3H]-E2 as substrate in presence of NAD+ by radio-HPLC analysis relative to control
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by Target
Selectivity ratio of IC50 for 17beta-HSD2 in human MDA-MB-231 to IC50 for human placental microsomal fraction 17beta-HSD2
Assay data:4 Tested
Inhibition of 17beta-HSD2 in human MDA-MB-231 cells using [3H]-E2 as substrate after 6 hrs by radio-HPLC analysis
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
Assay data:23 Active, 2 Activity ≤ 1 nM, 23 Activity ≤ 1 µM, 23 Tested
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
Inhibition of human placental cytosolic 17beta-HSD2 at 1 uM using [3H]-E2/E2 substrate and NAD+ after 20 mins by HPLC based radio-detection method
Assay data:1 Tested
Inhibition of human placental cytosolic 17beta-HSD2 using [3H]-E2/E2 substrate and NAD+ after 20 mins by HPLC based radio-detection method
Assay data:13 Active, 13 Activity ≤ 1 µM, 13 Tested
Inhibition of recombinant human 17beta-HSD2 expressed in HEK293 cells using estradiol as substrate after 10 mins in presence of radiolabeled tracer substrate by scintillation counting method
Assay data:10 Active, 2 Activity ≤ 1 µM, 10 Tested
Inhibition of recombinant human 17beta-HSD2 expressed in HEK293 cells assessed as residual activity at 20 uM using estradiol as substrate after 10 mins in presence of radiolabeled tracer substrate by scintillation counting method relative to control
Assay data:21 Tested
Inhibition of human placental microsomal 17beta-HSD2 using [2,4,6,7-3H]-E2 as substrate after 20 mins in presence of NAD+ by RP-HPLC method
Assay data:32 Active, 32 Activity ≤ 1 µM, 32 Tested
Inhibition of human placental microsomal fraction 17beta-HSD2 at 100 nM using [3H]-E2 as substrate after 20 mins in presence of NAD+ by radio-flow detector based analysis relative to control
Assay data:6 Tested
Inhibition of human placental microsomal fraction 17beta-HSD2 using [3H]-E2 as substrate after 20 mins in presence of NAD+ by radio-flow detector based analysis
Assay data:36 Active, 3 Activity ≤ 1 nM, 36 Activity ≤ 1 µM, 36 Tested
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