BioAssay by Target (List) for Gene (Select 3326) - PubChem BioAssay - NCBI

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Select item 19575201.

Binding affinity to HSP90 (unknown origin)

Source:: ChEMBL

Protein Targets:: Heat shock protein HSP 90-alpha; ...
Total:: 2

Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested

AID:: 1957520

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19463172.

Binding affinity to full length HSP90 (unknown origin) expressed in Escherichia coli BL21(DE3) cells at 20 uM by NMR STD assay

Source:: ChEMBL

Protein Targets:: Heat shock protein HSP 90-alpha; ...
Total:: 2

Assay data:1 Active, 1 Tested

AID:: 1946317

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 19463153.

Inhibition of HSP90 in human HL-60 cells assessed as decrease in CDK4 protein expression incubated for 24 hrs by western blot analysis

Source:: ChEMBL

Protein Targets:: Heat shock protein HSP 90-alpha; ...
Total:: 2

Assay data:2 Tested

AID:: 1946315

Summary PubMed Citation Related BioAssays by Target

Select item 19463144.

Inhibition of HSP90 in human HL-60 cells assessed as increase in HSP27 protein expression incubated for 24 hrs by western blot analysis

Source:: ChEMBL

Protein Targets:: Heat shock protein HSP 90-alpha; ...
Total:: 2

Assay data:2 Tested

AID:: 1946314

Summary PubMed Citation Related BioAssays by Target

Select item 19377705.

Inhibition of HSP90 (unknown origin)

Source:: ChEMBL

Protein Targets:: Heat shock protein HSP 90-alpha; ...
Total:: 2

Assay data:1 Active, 1 Activity ≤ 1 µM, 3 Tested

AID:: 1937770

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19369156.

Binding affinity to HSP90beta (unknown origin)

Source:: ChEMBL

Protein Target:: Heat shock protein HSP 90-beta

Assay data:24 Active, 5 Activity ≤ 1 µM, 42 Tested

AID:: 1936915

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19316807.

Inhibition of human HSP90

Source:: ChEMBL

Protein Targets:: Heat shock protein HSP 90-alpha; ...
Total:: 2

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1931680

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19316778.

Inhibition of HSP90 (unknown origin)

Source:: ChEMBL

Protein Targets:: Heat shock protein HSP 90-alpha; ...
Total:: 2

Assay data:1 Active, 1 Tested

AID:: 1931677

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 19291409.

Disruption of HSP90 and Cdc37 in human MDA-MB-231 cells assessed as increase of caspase 9 release at 200 nM measured by Western blot assay

Source:: ChEMBL

Protein Targets:: Heat shock protein HSP 90-beta; ...
Total:: 2

Assay data:1 Active, 1 Tested

AID:: 1929140

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 192913910.

Disruption of HSP90 and Cdc37 in human MDA-MB-231 cells assessed as increase of caspase 9 release at 100 nM measured by Western blot assay

Source:: ChEMBL

Protein Targets:: Heat shock protein HSP 90-beta; ...
Total:: 2

Assay data:1 Active, 1 Tested

AID:: 1929139

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 192913811.

Disruption of HSP90 and Cdc37 in human MDA-MB-231 cells assessed as increase of caspase 3 release at 200 nM measured by Western blot assay

Source:: ChEMBL

Protein Targets:: Heat shock protein HSP 90-beta; ...
Total:: 2

Assay data:1 Active, 1 Tested

AID:: 1929138

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 192913712.

Disruption of HSP90 and Cdc37 in human MDA-MB-231 cells assessed as increase of caspase 3 release at 100 nM measured by Western blot assay

Source:: ChEMBL

Protein Targets:: Heat shock protein HSP 90-beta; ...
Total:: 2

Assay data:1 Active, 1 Tested

AID:: 1929137

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 192913613.

Disruption of HSP90 and Cdc37 in human MDA-MB-231 cells assessed as increase of cytochrome C release at 200 nM measured by Western blot assay

Source:: ChEMBL

Protein Targets:: Heat shock protein HSP 90-beta; ...
Total:: 2

Assay data:1 Active, 1 Tested

AID:: 1929136

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 192913514.

Disruption of HSP90 and Cdc37 in human MDA-MB-231 cells assessed as increase of cytochrome C release at 100 nM measured by Western blot assay

Source:: ChEMBL

Protein Targets:: Heat shock protein HSP 90-beta; ...
Total:: 2

Assay data:1 Active, 1 Tested

AID:: 1929135

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 192913415.

Disruption of HSP90 and Cdc37 in human MDA-MB-231 cells assessed as increase of Bax/Bcl2 ratio at 200 nM measured by Western blot assay

Source:: ChEMBL

Protein Targets:: Heat shock protein HSP 90-beta; ...
Total:: 2

Assay data:1 Active, 1 Tested

AID:: 1929134

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 192913316.

Disruption of HSP90 and Cdc37 in human MDA-MB-231 cells assessed as increase of Bax/Bcl2 ratio at 100 nM measured by Western blot assay

Source:: ChEMBL

Protein Targets:: Heat shock protein HSP 90-beta; ...
Total:: 2

Assay data:1 Active, 1 Tested

AID:: 1929133

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 192913217.

Disruption of HSP90 and Cdc37 in human MDA-MB-231 cells assessed as decrease of CDK4 expression measured by Western blot assay

Source:: ChEMBL

Protein Targets:: Heat shock protein HSP 90-beta; ...
Total:: 2

Assay data:1 Tested

AID:: 1929132

Summary PubMed Citation Related BioAssays by Target

Select item 192913118.

Disruption of HSP90 and Cdc37 in human MDA-MB-231 cells assessed as decrease of phosphorylated AKT expression measured by Western blot analysis

Source:: ChEMBL

Protein Targets:: Heat shock protein HSP 90-beta; ...
Total:: 2

Assay data:1 Tested

AID:: 1929131

Summary PubMed Citation Related BioAssays by Target

Select item 192913019.

Disruption of HSP90 and Cdc37 in human MDA-MB-231 cells at 200 nM measured after 48 hrs by immunoprecipitation method

Source:: ChEMBL

Protein Targets:: Heat shock protein HSP 90-beta; ...
Total:: 2

Assay data:1 Active, 1 Tested

AID:: 1929130

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 192912020.

Disruption of His-tagged full length HSP90 (unknown origin)/GST-tagged Cdc37 (unknown origin) measured after 1 hr by HTRF method

Source:: ChEMBL

Protein Targets:: Heat shock protein HSP 90-beta; ...
Total:: 2

Assay data:6 Active, 6 Tested

AID:: 1929120

Summary Compounds, Active PubMed Citation Related BioAssays by Target

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Target

Proteins (3)
BioAssays with protein sequences specified as targets
RNAi Target, Active (6)
BioAssays with gene sequences specified as RNAi targets and the activity is active

BioActivity

Active Compounds (765)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (11)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (177)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Summary (1)
BioAssays summarizing information from multiple assays for validated chemical probes or small molecule leads
Confirmatory (248)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
Primary Screening (10)
Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose
Chemical Screens (1,316)
BioAssays reporting BioActivity of chemical reagents
RNAi Screens (13)
BioAssays reporting BioActivity of RNAi reagents

Assay Project (1)
BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

Depositor Category

Literature Extraction (1,312)
BioAssays extracted from the literature
NIH MLP (4)
BioAssays deposited by the NIH Molecular Libraries Program
Other (13)
BioAssays deposited by other experimentalists

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BioAssay by Target (List) for Gene (Select 3326) (1329)
PubChem BioAssay
Gene neighbors for Gene (Select 3326) (11)
Gene
tRNA (cytosine(38)-C(5))-methyltransferase isoform X9 [Homo sapiens]
tRNA (cytosine(38)-C(5))-methyltransferase isoform X9 [Homo sapiens]
gi|2217275770|ref|XP_047280654.1|

Protein
Homo sapiens tRNA aspartic acid methyltransferase 1 (TRDMT1), transcript variant...
Homo sapiens tRNA aspartic acid methyltransferase 1 (TRDMT1), transcript variant a, mRNA
gi|1519244125|ref|NM_004412.7|

Nucleotide
Maylandia zebra isolate Zi1084z NADH dehydrogenase subunit 2 (ND2) gene, complet...
Maylandia zebra isolate Zi1084z NADH dehydrogenase subunit 2 (ND2) gene, complete cds; mitochondrial
gi|270311940|gb|GU192222.1|

Nucleotide

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