BioAssay by Target (List) for Gene (Select 3363) - PubChem BioAssay - NCBI

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Select item 19194231.

Radioligand Binding Assay from US Patent US11642336: "5-HT2A agonists for use in treatment of depression"

Source:: BindingDB

Protein Targets:: 5-hydroxytryptamine receptor 1A; ...
Total:: 19

Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested

AID:: 1919423

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19170772.

Displacement of [3H]-5Carboxyamidotryptamine from human 5-HT7R expressed in HEK293 cells by radioligand binding assay

Source:: ChEMBL

Protein Target:: 5-hydroxytryptamine receptor 7

Assay data:3 Active, 1 Activity ≤ 1 µM, 6 Tested

AID:: 1917077

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19164663.

Displacement of [3H]LSD from 5-HT7R (unknown origin) assessed as inhibition constant by competition binding assay

Source:: ChEMBL

Protein Target:: 5-hydroxytryptamine receptor 7

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1916466

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19164614.

Binding affinity to human 5-HT7R assessed as inhibition constant

Source:: ChEMBL

Protein Target:: 5-hydroxytryptamine receptor 7

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1916461

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19164555.

Binding affinity to 5-HT7R (unknown origin) assessed as inhibition constant

Source:: ChEMBL

Protein Target:: 5-hydroxytryptamine receptor 7

Assay data:6 Active, 2 Activity ≤ 1 nM, 6 Activity ≤ 1 µM, 7 Tested

AID:: 1916455

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19149296.

Selectivity interaction (GPCR panel (PDSP screen)) EUB0000317b HTR7

Source:: ChEMBL

Protein Target:: 5-hydroxytryptamine receptor 7

Assay data:1 Tested

AID:: 1914929

Summary Related BioAssays by Target

Select item 19148857.

Selectivity interaction (GPCR panel (PDSP screen)) EUB0000252b HTR7

Source:: ChEMBL

Protein Target:: 5-hydroxytryptamine receptor 7

Assay data:1 Tested

AID:: 1914885

Summary Related BioAssays by Target

Select item 19146308.

Selectivity interaction (GPCR panel (PDSP screen)) EUB0000747a HTR7

Source:: ChEMBL

Protein Target:: 5-hydroxytryptamine receptor 7

Assay data:1 Tested

AID:: 1914630

Summary Related BioAssays by Target

Select item 19146069.

Selectivity interaction (GPCR panel (PDSP screen)) EUB0000744a HTR7

Source:: ChEMBL

Protein Target:: 5-hydroxytryptamine receptor 7

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1914606

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 191458210.

Selectivity interaction (GPCR panel (PDSP screen)) EUB0000743a HTR7

Source:: ChEMBL

Protein Target:: 5-hydroxytryptamine receptor 7

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1914582

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 191456011.

Selectivity interaction (GPCR panel (PDSP screen)) EUB0000741a HTR7

Source:: ChEMBL

Protein Target:: 5-hydroxytryptamine receptor 7

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1914560

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 191434712.

Selectivity interaction (CEREP panel (kinases, GPCRs, ion channels, transporters)) EUB0000211b HTR7

Source:: ChEMBL

Protein Target:: 5-hydroxytryptamine receptor 7

Assay data:1 Tested

AID:: 1914347

Summary Related BioAssays by Target

Select item 191239413.

Binding affinity to 5-HT7 receptor (unknown origin) at 10000 nM by radioligand displacement assay relative to control

Source:: ChEMBL

Protein Target:: 5-hydroxytryptamine receptor 7

Assay data:1 Tested

AID:: 1912394

Summary PubMed Citation Related BioAssays by Target

Select item 191096214.

Inhibition of serotonin 5-HT7A receptor (unknown origin) at 10 uM relative to control

Source:: ChEMBL

Protein Target:: 5-hydroxytryptamine receptor 7

Assay data:1 Tested

AID:: 1910962

Summary PubMed Citation Related BioAssays by Target

Select item 190705015.

Binding affinity to 5-HT7BR (unknown origin) assessed as inhibition constant

Source:: ChEMBL

Protein Target:: 5-hydroxytryptamine receptor 7

Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested

AID:: 1907050

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 190703916.

Displacement of [3H]-5-CT from human full length 5HT7BR expressed in HEK293 cells by radioligand binding assay

Source:: ChEMBL

Protein Target:: 5-hydroxytryptamine receptor 7

Assay data:13 Active, 11 Activity ≤ 1 µM, 15 Tested

AID:: 1907039

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 189036017.

Displacement of [3H]-5-CT from human 5-HT7 receptor expressed in CHO-K1 cells membrane by scintillation counter analysis

Source:: ChEMBL

Protein Target:: 5-hydroxytryptamine receptor 7

Assay data:13 Active, 24 Activity ≤ 1 µM, 24 Tested

AID:: 1890360

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 188969118.

Displacement of [3H]-5-CT from human 5-HT7b receptor expressed in HEK293 cells measured after 1 hr by Microbeta plate reader method

Source:: ChEMBL

Protein Target:: 5-hydroxytryptamine receptor 7

Assay data:4 Active, 4 Activity ≤ 1 µM, 5 Tested

AID:: 1889691

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 188015419.

Binding affinity to 5HT7 receptor (unknown origin) assessed as inhibition constant

Source:: ChEMBL

Protein Target:: 5-hydroxytryptamine receptor 7

Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested

AID:: 1880154

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 186588420.

Binding affinity to 5-HT7 receptor (unknown origin)

Source:: ChEMBL

Protein Target:: 5-hydroxytryptamine receptor 7

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1865884

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

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Target

Proteins (4)
BioAssays with protein sequences specified as targets
RNAi Target, Active (6)
BioAssays with gene sequences specified as RNAi targets and the activity is active

BioActivity

Active Compounds (444)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (92)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (393)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Summary (1)
BioAssays summarizing information from multiple assays for validated chemical probes or small molecule leads
Confirmatory (476)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
Primary Screening (10)
Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose
Chemical Screens (775)
BioAssays reporting BioActivity of chemical reagents
RNAi Screens (14)
BioAssays reporting BioActivity of RNAi reagents

Assay Project (4)
BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

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Literature Extraction (746)
BioAssays extracted from the literature
NIH MLP (4)
BioAssays deposited by the NIH Molecular Libraries Program
Other (39)
BioAssays deposited by other experimentalists

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