BioAssay by Target (List) for Gene (Select 3551) - PubChem BioAssay - NCBI

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Select item 19624131.

IKBKB Invitrogen Lab (UK) kinase screen (BI)

Source:: ChEMBL

Protein Target:: Inhibitor of nuclear factor kappa-B kinase subunit beta

Assay data:1 Tested

AID:: 1962413

Summary Related BioAssays by Target

Select item 19622662.

IKBKB Invitrogen Lab (UK) kinase screen (BI)

Source:: ChEMBL

Protein Target:: Inhibitor of nuclear factor kappa-B kinase subunit beta

Assay data:1 Tested

AID:: 1962266

Summary Related BioAssays by Target

Select item 19490263.

Inhibition of IKK2 (unknown origin) by Ambit kinase assay

Source:: ChEMBL

Protein Target:: Inhibitor of nuclear factor kappa-B kinase subunit beta

Assay data:3 Tested

AID:: 1949026

Summary PubMed Citation Related BioAssays by Target

Select item 19408684.

Inhibition of IKKB (unknown origin)

Source:: ChEMBL

Protein Target:: Inhibitor of nuclear factor kappa-B kinase subunit beta

Assay data:2 Activity ≤ 1 µM, 2 Tested

AID:: 1940868

Summary Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19198055.

Kinase (PDGFRα, PDGFRβ, ABL1 and FLT3) Inhibition Test of Compounds from US Patent US20230312529: "PYRIMIDINE SMALL-MOLECULE COMPOUND AND APPLICATION THEREOF"

Source:: BindingDB

Protein Targets:: ALK tyrosine kinase receptor; ...
Total:: 6

Assay data:13 Active, 13 Activity ≤ 1 µM, 13 Tested

AID:: 1919805

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19195356.

In Vitro Kinase Activity Assay from US Patent US11691950: "Isoquinoline-steroid conjugates and uses thereof"

Source:: BindingDB

Protein Targets:: Inhibitor of nuclear factor kappa-B kinase subunit beta; ...
Total:: 16

Assay data:21 Active, 18 Activity ≤ 1 µM, 21 Tested

AID:: 1919535

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19154357.

Selectivity interaction (Kinase Panel (competition binding assay)) EUB0000589aTFA IKBKB

Source:: ChEMBL

Protein Target:: Inhibitor of nuclear factor kappa-B kinase subunit beta

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1915435

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19135008.

Selectivity interaction (Enzymatic assay) EUB0000624a IKBKB

Source:: ChEMBL

Protein Target:: Inhibitor of nuclear factor kappa-B kinase subunit beta

Assay data:1 Tested

AID:: 1913500

Summary Related BioAssays by Target

Select item 19133679.

Affinity Biochemical interaction (Competition binding assay) EUB0000589aTFA IKBKB

Source:: ChEMBL

Protein Target:: Inhibitor of nuclear factor kappa-B kinase subunit beta

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1913367

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 191285810.

Affinity Phenotypic Cellular interaction (Immunoblotting (inhibition of CHUK phosphorylation in THP-1 cells)) EUB0000589aTFA IKBKB

Source:: ChEMBL

Protein Target:: Inhibitor of nuclear factor kappa-B kinase subunit beta

Assay data:1 Active, 1 Tested

AID:: 1912858

Summary Compounds, Active Related BioAssays by Target

Select item 190239511.

Inhibition of IKKbeta (unknown origin) at 50 nM by Z'LYTE screening method relative to control

Source:: ChEMBL

Protein Target:: Inhibitor of nuclear factor kappa-B kinase subunit beta

Assay data:3 Tested

AID:: 1902395

Summary PubMed Citation Related BioAssays by Target

Select item 190150012.

Inhibition of recombinant human full length IKKbeta assessed as residual activity at 1 uM using peptide as substrate incubated for 40 mins in presence of [gamma 33P]-ATP by radiometric scintillation counting assay relative to control

Source:: ChEMBL

Protein Target:: Inhibitor of nuclear factor kappa-B kinase subunit beta

Assay data:1 Tested

AID:: 1901500

Summary PubMed Citation Related BioAssays by Target

Select item 189829613.

Inhibition of human IKKbeta assessed as residual activity at 30 uM relative to control

Source:: ChEMBL

Protein Target:: Inhibitor of nuclear factor kappa-B kinase subunit beta

Assay data:1 Tested

AID:: 1898296

Summary PubMed Citation Related BioAssays by Target

Select item 189426514.

Inhibition of IKK2 (unknown origin)

Source:: ChEMBL

Protein Target:: Inhibitor of nuclear factor kappa-B kinase subunit beta

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1894265

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 186708315.

Covalent modification of N-terminal hexa-his-tagged human recombinant IKKbeta assessed as high molecular weight band formation at 1:10 protein to compound concentration measured after 24 hrs by SDS-PAGE based silver staining analysis

Source:: ChEMBL

Protein Target:: Inhibitor of nuclear factor kappa-B kinase subunit beta

Assay data:1 Tested

AID:: 1867083

Summary PubMed Citation Related BioAssays by Target

Select item 186708016.

Covalent modification of N-terminal hexa-his-tagged human recombinant IKKbeta assessed as high molecular weight band formation at 1:1 protein to compound concentration measured after 24 hrs by SDS-PAGE based silver staining analysis

Source:: ChEMBL

Protein Target:: Inhibitor of nuclear factor kappa-B kinase subunit beta

Assay data:1 Active, 1 Tested

AID:: 1867080

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 186044317.

Inhibition of IKBKB (unknown origin) at 0.5 uM relative to control

Source:: ChEMBL

Protein Target:: Inhibitor of nuclear factor kappa-B kinase subunit beta

Assay data:1 Tested

AID:: 1860443

Summary PubMed Citation Related BioAssays by Target

Select item 183572818.

IKK-beta DiscoveRx kinase panel

Source:: ChEMBL

Protein Target:: Inhibitor of nuclear factor kappa-B kinase subunit beta

Assay data:1 Tested

AID:: 1835728

Summary Related BioAssays by Target

Select item 183499919.

IKKbeta(h) Kinase panel

Source:: ChEMBL

Protein Target:: Inhibitor of nuclear factor kappa-B kinase subunit beta

Assay data:1 Tested

AID:: 1834999

Summary Related BioAssays by Target

Select item 183416920.

Inhibition of IKKbeta (unknown origin) at 1 uM

Source:: ChEMBL

Protein Target:: Inhibitor of nuclear factor kappa-B kinase subunit beta

Assay data:1 Tested

AID:: 1834169

Summary PubMed Citation Related BioAssays by Target

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Target

Proteins (4)
BioAssays with protein sequences specified as targets
RNAi Target, Active (8)
BioAssays with gene sequences specified as RNAi targets and the activity is active

BioActivity

Active Compounds (198)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (8)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (129)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Summary (1)
BioAssays summarizing information from multiple assays for validated chemical probes or small molecule leads
Confirmatory (248)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
Primary Screening (63)
Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose
Chemical Screens (682)
BioAssays reporting BioActivity of chemical reagents
RNAi Screens (73)
BioAssays reporting BioActivity of RNAi reagents

Assay Project (9)
BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

Depositor Category

Literature Extraction (633)
BioAssays extracted from the literature
NIH MLP (4)
BioAssays deposited by the NIH Molecular Libraries Program
Other (117)
BioAssays deposited by other experimentalists

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BioAssay by Target (List) for Gene (Select 3551) (755)
PubChem BioAssay
Gene Links for GEO Profiles (Select 127756556) (1)
Gene
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing ...
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1 [Homo sapiens]
Gene ID:64780

Gene
Gene Links for GEO Profiles (Select 30692336) (0)
Gene
inhibitor of nuclear factor kappa-B kinase subunit beta isoform X4 [Homo sapiens...
inhibitor of nuclear factor kappa-B kinase subunit beta isoform X4 [Homo sapiens]
gi|2462619309|ref|XP_054216405.1|

Protein

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