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Agonist activity at human CD137 expressed in Jurkat T cells co-expressing response element driven luciferase reporter gene assessed as fold change in Emax at 1:1 Nectin-4/CD137 ratio measured after 6 hrs by HT1376/CD137 reporter co-culture assay
Assay data:1 Tested
SummaryPubMed Citation
Agonist activity at human CD137 expressed in Jurkat T cells co-expressing response element driven luciferase reporter gene assessed as fold change in EC50 at 1:1 Nectin-4/CD137 ratio measured after 6 hrs by HT1376/CD137 reporter co-culture assay
Agonist activity at human CD137 expressed in Jurkat T cells co-expressing response element driven luciferase reporter gene assessed as luminescence measured after 6 hrs by HT1376/CD137 reporter co-culture assay
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Binding affinity to human recombinant CD137 by surface plasmon resonance analysis
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Binding affinity to human CD137 assessed as dissociation constant by surface plasmon resonance analysis
Assay data:1 Active, 2 Tested
SummaryCompounds, ActivePubMed Citation
Induction of recombinant human CD137 assessed as increase in fold change in Emax incubated for 1 hrs by luminescence based microplate reader assay
Induction of recombinant human CD137 assessed as increase in fold change in EC50 incubated for 1 hrs by luminescence based microplate reader assay
Binding affinity to human CD137 assessed as dissociation constant using 1:1 Nectin-4/CD137 by surface plasmon resonance analysis
Agonist activity at human CD137 expressed in human NCI-H292 cells measured after 6 hrs by fluorescence microplate reader assay
Assay data:1 Active, 1 Tested
Agonist activity at human CD137 expressed in human HT-1376 cells measured after 6 hrs by fluorescence microplate reader assay
Agonist activity at recombinant human CD137 expressed in Jurkat T cells co-expressing response element driven luciferase reporter gene co-cultured with Nectin-4 expressing mouse MC38 cells assessed as luminescence measured after 6 hrs by luciferase reporter gene based co-culture assay
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
Human 4-1BB (Tumour necrosis factor (TNF) receptor family)
Assay data:2 Active, 2 Tested
SummaryPubMed CitationRelated BioAssays by Target
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced TNF-alpha response in human macrophages_Primary screen TNF readout
Assay data:2853 Active, 18113 Tested
SummaryRelated BioAssays by Same Project
A screen to identify synthetic lethal interactions with E-cadherin in an MCF10A isogenic cell line
Assay data:2442 Active, 18052 Tested
A screen to identify genes that regulate lymphatic endothelial cell migration - Primary Screen
Assay data:1034 Active, 18120 Tested
SummaryRelated BioAssays by Depositor
Identification of proteins required for the processing of the EWS-FLI1 nascent transcript
Assay data:59220 Tested
InfectX: Pathogen infection siRNA screens
Assay data:115372 Tested
A whole genome RNAi screen highlights components of the ER/Golgi as a prominent source of resistance to immunotoxin-mediated cytotoxicity
Assay data:555 Active, 64752 Tested
RNAi screen for vorinostat resistance genes - Primary Screen
Assay data:450 Active, 18118 Tested
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