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Biochemical Assay from US Patent US11524945: "Compounds for treating ILK-mediated diseases"
Assay data:9 Active, 4 Activity ≤ 1 µM, 10 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
In Vitro Ezyme Assay from US Patent US8754233: "Pyrazolylbenzothiazole derivatives and their use as therapeutic agents"
Assay data:151 Active, 104 Activity ≤ 1 µM, 151 Tested
Induction of ILK (unknown origin)
Assay data:8 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of ILK (unknown origin)
Assay data:2 Active, 2 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Modulation of ILK in human mesangial cells assessed as reduction in AKT phosphorylation at Ser473 residue at 50 uM measured upto 90 mins by Western blot analysis
Assay data:1 Tested
Modulation of ILK in human mesangial cells assessed as reduction in GSK-3beta phosphorylation at ser9 residue at 50 uM measured upto 90 mins by Western blot analysis
Inhibition of ILK in human NCI-H929 cells at 10 uM by mass spectroscopic analysis relative to control
Assay data:6 Tested
SummaryRelated BioAssays by Target
Inhibition of ILK in human NCI-H929 cells by mass spectroscopic analysis
Assay data:1 Active, 6 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
Inhibition of ILK in human SKCO1 cells at 1 uM after 4 hrs using biotin labeled WQGNDIVVKVLK probe by mass-spectrometric analysis relative to control
Assay data:3 Tested
Inhibition of ILK protein kinase domain (unknown origin) at 10 uM
Inhibition of ILK Lysine 1 labelling site (unknown origin) at 10 uM
Inhibition of ILK Protein Kinase Domain (ISMADVKFSFQCPGR) in human PBMC at 0.1 uM
Inhibition of ILK conserved Lys1 (WQGNDIVVKVLK) in human PBMC at 0.1 uM
Inhibition of ILK Protein Kinase Domain (ISMADVKFSFQCPGR) in human PBMC at 1 uM
Inhibition of ILK conserved Lys1 (WQGNDIVVKVLK) in human PBMC at 1 uM
Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.
Assay data:3 Active, 2 Activity ≤ 1 µM, 217 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Human integrin linked kinase (ILK subfamily)
Assay data:1 Active, 1 Tested
Inhibition of full-length recombinant human GST-tagged ILK1 expressed in baculovirus infected insect Hi5 cells using CKRRRLASLR-amide as substrate after 15 mins by scintillation counting analysis in presence of [gamma-32P]-ATP
Assay data:152 Active, 105 Activity ≤ 1 µM, 152 Tested
Inhibition of full length recombinant GST-tagged ILK (unknown origin) expressed in baculovirus infected insect Sf9 cells using CKRRRLASLR as substrate incubated for 15 mins by scintillation counting analysis in presence of radiolabelled phosphate
Assay data:1 Active, 1 Activity ≤ 1 µM, 17 Tested
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