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Inhibition of alphavbeta5 integrin receptor-mediated cell adhesion to vitronectin in human HT-29 cells
Assay data:1 Active, 1 Activity ≤ 1 µM, 4 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Solid Phase Receptor Assay (SPRA) for alphavbeta5 Function from US Patent US10577330: "Meta-azacyclic amino benzoic acid derivatives as pan integrin antagonists"
Assay data:28 Active, 21 Activity ≤ 1 nM, 28 Activity ≤ 1 µM, 28 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Solid Phase Receptor Assay (SPRA) for alphaVbeta5 from US Patent US10035778: "Meta-azacyclic amino benzoic acid derivatives as pan integrin antagonists"
Assay data:17 Active, 17 Activity ≤ 1 nM, 17 Activity ≤ 1 µM, 17 Tested
Inhibition of human alphavbeta5 integrin stably expressed in human K562 cells assessed as inhibition of cell adhesion to vitronectin incubated for 30 mins by BCECF-AM staining based fluorescence assay
Assay data:6 Active, 6 Activity ≤ 1 µM, 6 Tested
Inhibition of integrin alphavbeta5 (unknown origin) by fluorescence polarization assay
Assay data:33 Active, 31 Activity ≤ 1 µM, 33 Tested
Inhibition of alphavbeta5 integrin (unknown origin) by solid phase binding assay
Assay data:3 Active, 2 Activity ≤ 1 µM, 5 Tested
Inhibition of fibrinogen binding to alphaVbeta5 isolated form human mCf7 cells incubated for 1 hr by scintillation-proximity assay based competitive solid-phase binding assay
Assay data:5 Active, 11 Activity ≤ 1 µM, 12 Tested
Antagonist activity at alphaVbeta5 in human MCF7 cells assessed as reduction in cell adhesion to fibrinogen pre-incubated for 30 mins before fibrinogen and further incubated for 1 hr by nitrophenyl-N-acetyl-beta-D-glucosaminide substrate based chromogenic assay
Assay data:3 Active, 2 Activity ≤ 1 µM, 15 Tested
Agonist activity at alphaVbeta5 in human MCF7 cells assessed as increase in cell adhesion to fibrinogen pre-incubated for 30 mins before fibrinogen and further incubated for 1 hr by nitrophenyl-N-acetyl-beta-D-glucosaminide substrate based chromogenic assay
Assay data:4 Active, 4 Activity ≤ 1 µM, 16 Tested
Inhibition of vitronectin binding to recombinant human integrin alphaV (Phe31 to Val992 residues) beta5 (Gly24 to Asn719 residues) expressed in CHO cells by ELISA based solid phase binding assay
Assay data:6 Active, 5 Activity ≤ 1 µM, 6 Tested
Inhibition of human vitronectin binding to human integrin alphavbeta5 receptor after 1 hr by solid-phase binding assay
Assay data:6 Activity ≤ 1 µM, 6 Tested
SummaryCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of integrin alphavbeta5 (unknown origin) expressed in human K562 cells assessed as reduction in cell adhesion to human vitronectin incubated for 30 mins by fluorescent probe BCECF-AM based fluorescence assay
Assay data:9 Active, 9 Activity ≤ 1 µM, 10 Tested
Antagonist activity at integrin alphavbeta5 (unknown origin) expressed in human K562 cells assessed as reduction in cell adhesion to vitronectin by fluorescent probe BCECF-AM based fluorescence assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of ligand binding to integrin alphavbeta5 (unknown origin) expressed in baculovirus expression system after 2 hrs by solid-phase assay
Inhibition of integrin alphavbeta5 (unknown origin) by radioligand binding assay
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
Binding affinity alphav/beta5 integrin in human A375PPuro cells at 1000 nM after 15 mins by flow cytometric analysis
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Antagonist activity at integrin alphaVbeta5 (unknown origin) expressed in HT-29 cells assessed as reduction in cell adhesion to vitronectin after 2 hrs by MTT assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 8 Tested
Antagonist activity at integrin alphaVbeta3alphaVbeta5 (unknown origin) expressed in SKOV3 cells assessed as reduction in cell adhesion to fibrinogen after 2 hrs by MTT assay
Assay data:2 Active, 1 Activity ≤ 1 µM, 8 Tested
Displacement of biotinylated vitronectin from human integrin alphaVbeta5 measured after 3 hrs by solid-phase receptor binding assay
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