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Enzyme Assay from US Patent US11884671: "Purinone compounds and their use in treating cancer"
Assay data:51 Tested
SummaryRelated BioAssays by DepositorRelated BioAssays by Target
In Vitro Activity Assay of JAK1, JAK2, JAK3, TYK2 Kinases from US Patent US20240002404: "SALT OF PYRROLOPYRIMIDINE COMPOUND, CRYSTALLINE FORM THEREOF, AND APPLICATION THEREOF"
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Inhibitory Activity Assay from US Patent US20230416237: "AMIDE COMPOUND, PHARMACEUTICAL COMPOSITION AND USE THEREOF"
Assay data:37 Active, 36 Activity ≤ 1 µM, 37 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Kinase Inhibitory Activity Assay from US Patent US20230348487: "2-AMINOPYRIMIDINE COMPOUND AND PHARMACEUTICAL COMPOSITION THEREOF AND APPLICATION THEREOF"
Assay data:45 Active, 43 Activity ≤ 1 µM, 46 Tested
Biochemical JAK and Off-Target Kinase Assay from US Patent US11780852: "Methods for treating Crohn's disease using 3-((1R,3s,5S)-3-((7-((5-methyl-1H-pyrazol-3-yl)amino)-1,6-naphthyridin-5-yl)amino)-8-azabicyclo[3.2.1]octan-8-yl)propanenitrile"
Assay data:281 Active, 268 Activity ≤ 1 nM, 281 Activity ≤ 1 µM, 281 Tested
JAK/TYK2 Assay from US Patent US11780842: "TYK2 pseudokinase ligands"
Assay data:34 Active, 23 Activity ≤ 1 µM, 34 Tested
Kinase (PDGFRα, PDGFRβ, ABL1 and FLT3) Inhibition Test of Compounds from US Patent US20230312529: "PYRIMIDINE SMALL-MOLECULE COMPOUND AND APPLICATION THEREOF"
Assay data:13 Active, 13 Activity ≤ 1 µM, 13 Tested
JAK1, JAK2, and JAK3 Activity from US Patent US20230295119: "SUBSTITUTED PYRIDINES FOR THE TREATMENT OF INFLAMMATORY DISEASES"
Assay data:314 Active, 329 Activity ≤ 1 µM, 329 Tested
JAK1 JH2 and JAK2 JH1 Domain Binding Assay from US Patent US11731956: "Substituted 1,2,4-triazoles as intermediates in the synthesis of TYK2 inhibitors"
Assay data:11 Active, 11 Activity ≤ 1 µM, 11 Tested
JAK Enzyme Assay from US Patent US11731943: "Therapeutic compounds, compositions and methods of use thereof"
Assay data:278 Active, 108 Activity ≤ 1 nM, 298 Activity ≤ 1 µM, 298 Tested
Biochemical Assay from US Patent US11718616: "JAK kinase inhibitor compounds for treatment of respiratory disease"
Assay data:27 Active, 27 Activity ≤ 1 nM, 27 Activity ≤ 1 µM, 27 Tested
Biochemical JAK Kinase Assays from US Patent US11713315: "5 to 7 membered heterocyclic amides as JAK inhibitors"
Assay data:12 Active, 12 Activity ≤ 1 nM, 12 Activity ≤ 1 µM, 12 Tested
LanthaScreen JAK Biochemical Assays (JAK1, 2, 3 and Tyk2) from US Patent US11702415: "Crystalline hydrate of a JAK inhibitor compound"
Assay data:2 Active, 2 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested
Biochemical JAK and Tyk2 Kinase Assays from US Patent US11697648: "Fused pyrimidine pyridinone compounds as JAK inhibitors"
Assay data:264 Active, 259 Activity ≤ 1 nM, 264 Activity ≤ 1 µM, 264 Tested
In Vitro Kinase Activity Assay from US Patent US11691950: "Isoquinoline-steroid conjugates and uses thereof"
Assay data:21 Active, 18 Activity ≤ 1 µM, 21 Tested
Enzyme Inhibition from US Patent US11673870: "Pharmaceutical compounds"
Assay data:21 Active, 21 Activity ≤ 1 µM, 21 Tested
Biochemical JAK Kinase Assay from US Patent US11667637: "Fused imidazo-piperidine JAK inhibitors"
Assay data:11 Active, 11 Activity ≤ 1 nM, 11 Activity ≤ 1 µM, 11 Tested
JAK Family Caliper Enzyme Assay from US Patent US11655252: "Aminopyrimidinyl derivatives"
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
JAK Enzyme Assay from US Patent US11649241: "Pyrazolochlorophenyl compounds, compositions and methods of use thereof"
Assay data:14 Active, 12 Activity ≤ 1 nM, 14 Activity ≤ 1 µM, 14 Tested
HotSpot Kinase Assay from US Patent US11643396: "BRD4-kinase inhibitors as cancer therapeutics"
Assay data:6 Active, 2 Activity ≤ 1 nM, 6 Activity ≤ 1 µM, 6 Tested
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