BioAssay by Target (List) for Gene (Select 3753) - PubChem BioAssay - NCBI

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Select item 17544801.

Inhibition of KvLQT1/mink (unknown origin) by voltage clamp method

Source:: ChEMBL

Protein Targets:: Potassium voltage-gated channel subfamily E member 1; ...
Total:: 2

Assay data:1 Tested

AID:: 1754480

Summary PubMed Citation Related BioAssays by Target

Select item 16993572.

Activation of human KvLQT1/mink at 2 uM by thallium flux assay

Source:: ChEMBL

Protein Targets:: Potassium voltage-gated channel subfamily E member 1; ...
Total:: 2

Assay data:1 Tested

AID:: 1699357

Summary PubMed Citation Related BioAssays by Target

Select item 16993563.

Inhibition of human KvLQT1/mink at 2 uM by thallium flux assay

Source:: ChEMBL

Protein Targets:: Potassium voltage-gated channel subfamily E member 1; ...
Total:: 2

Assay data:1 Tested

AID:: 1699356

Summary PubMed Citation Related BioAssays by Target

Select item 16166354.

Inhibition of human KCNQ1/KCNE1

Source:: ChEMBL

Protein Targets:: Potassium voltage-gated channel subfamily E member 1; ...
Total:: 2

Assay data:1 Tested

AID:: 1616635

Summary PubMed Citation Related BioAssays by Target

Select item 15949485.

Inhibition of human KCNE1 by Ion-work electrophysiology assay

Source:: ChEMBL

Protein Target:: Potassium voltage-gated channel subfamily E member 1

Assay data:3 Tested

AID:: 1594948

Summary PubMed Citation Related BioAssays by Target

Select item 15941506.

Inhibition of IKs (unknown origin)

Source:: ChEMBL

Protein Target:: Potassium voltage-gated channel subfamily E member 1

Assay data:1 Active, 5 Tested

AID:: 1594150

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 15798697.

Inhibition of human minK expressed in CHOK1 cells at < 33 uM at -80 mV holding potential by Ionwork-based analysis

Source:: ChEMBL

Protein Target:: Potassium voltage-gated channel subfamily E member 1

Assay data:1 Tested

AID:: 1579869

Summary PubMed Citation Related BioAssays by Target

Select item 15537018.

Inhibition of human IKs by IonWork electrophysiology method

Source:: ChEMBL

Protein Target:: Potassium voltage-gated channel subfamily E member 1

Assay data:1 Tested

AID:: 1553701

Summary PubMed Citation Related BioAssays by Target

Select item 15085889.

RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen

Source:: Victorian Centre for Functional Genomics, Peter MacCallum Cancer Centre

Assay data:790 Active, 18119 Tested

AID:: 1508588

Select item 147195710.

Inhibition of IKs (unknown origin)

Source:: ChEMBL

Protein Target:: Potassium voltage-gated channel subfamily E member 1

Assay data:1 Tested

AID:: 1471957

Summary PubMed Citation Related BioAssays by Target

Select item 145844511.

Inhibition of KCNQ1/minK (unknown origin) by patch clamp assay

Source:: ChEMBL

Protein Targets:: Potassium voltage-gated channel subfamily E member 1; ...
Total:: 2

Assay data:1 Tested

AID:: 1458445

Summary PubMed Citation Related BioAssays by Target

Select item 143718012.

Inhibition of human KCNQ1/KCNE1 expressed in HEK293 cells assessed as reduction in slowly activating delayed rectifier cardiac potassium current at 10 uM by patch clamp electrophysiology method

Source:: ChEMBL

Protein Targets:: Potassium voltage-gated channel subfamily E member 1; ...
Total:: 2

Assay data:34 Tested

AID:: 1437180

Summary PubMed Citation Related BioAssays by Target

Select item 143717913.

Inhibition of human KCNQ1/KCNE1 expressed in HEK293 cells assessed as reduction in slowly activating delayed rectifier cardiac potassium current at 30 uM by patch clamp electrophysiology method

Source:: ChEMBL

Protein Targets:: Potassium voltage-gated channel subfamily E member 1; ...
Total:: 2

Assay data:1 Tested

AID:: 1437179

Summary PubMed Citation Related BioAssays by Target

Select item 143717814.

Inhibition of human KCNQ1/KCNE1 expressed in HEK293 cells assessed as reduction in slowly activating delayed rectifier cardiac potassium current by patch clamp electrophysiology method

Source:: ChEMBL

Protein Targets:: Potassium voltage-gated channel subfamily E member 1; ...
Total:: 2

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1437178

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 142363215.

Inhibition of IKs (unknown origin)

Source:: ChEMBL

Protein Target:: Potassium voltage-gated channel subfamily E member 1

Assay data:1 Tested

AID:: 1423632

Summary PubMed Citation Related BioAssays by Target

Select item 136788516.

Inhibition of human Kv7.1/minK at 10 uM by patch clamp method relative to control

Source:: ChEMBL

Protein Targets:: Potassium voltage-gated channel subfamily E member 1; ...
Total:: 2

Assay data:1 Tested

AID:: 1367885

Summary PubMed Citation Related BioAssays by Target

Select item 134001417.

Inhibition of human KCNQ1/KCNE1 expressed in HEK293 cells assessed as decrease in current amplitude at +40 mV by whole cell patch clamp method

Source:: ChEMBL

Protein Targets:: Potassium voltage-gated channel subfamily E member 1; ...
Total:: 2

Assay data:1 Tested

AID:: 1340014

Summary Related BioAssays by Target

Select item 134001318.

Inhibition of human KCNQ1/KCNE1 expressed in HEK293 cells assessed as decrease in current amplitude at +20 to +60 mV by whole cell patch clamp method

Source:: ChEMBL

Protein Targets:: Potassium voltage-gated channel subfamily E member 1; ...
Total:: 2

Assay data:1 Tested

AID:: 1340013

Summary Related BioAssays by Target

Select item 134001219.

Inhibition of human KCNQ1/KCNE1 expressed in HEK293 cells assessed as recovery of current amplitude at 30 uM measured after compound washout by whole cell patch clamp method

Source:: ChEMBL

Protein Targets:: Potassium voltage-gated channel subfamily E member 1; ...
Total:: 2

Assay data:1 Tested

AID:: 1340012

Summary Related BioAssays by Target

Select item 134001120.

Inhibition of human KCNQ1/KCNE1 expressed in HEK293 cells assessed as decrease in current amplitude at 30 uM by whole cell patch clamp method

Source:: ChEMBL

Protein Targets:: Potassium voltage-gated channel subfamily E member 1; ...
Total:: 2

Assay data:1 Active, 1 Tested

AID:: 1340011

Summary Compounds, Active Related BioAssays by Target

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Target

Proteins (4)
BioAssays with protein sequences specified as targets
RNAi Target, Active (7)
BioAssays with gene sequences specified as RNAi targets and the activity is active

BioActivity

Active Compounds (15)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 µM (4)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Summary (1)
BioAssays summarizing information from multiple assays for validated chemical probes or small molecule leads
Confirmatory (63)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
Primary Screening (12)
Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose
Chemical Screens (105)
BioAssays reporting BioActivity of chemical reagents
RNAi Screens (14)
BioAssays reporting BioActivity of RNAi reagents

Assay Project (5)
BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

Depositor Category

Literature Extraction (97)
BioAssays extracted from the literature
NIH MLP (5)
BioAssays deposited by the NIH Molecular Libraries Program
Other (17)
BioAssays deposited by other experimentalists

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