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IonWorks Quattro system from US Patent US11530213: "Naphthyridinone derivatives and their use in the treatment of arrhythmia"
Assay data:93 Active, 89 Activity ≤ 1 µM, 93 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Activation of GIRK1/4 channel (unknown origin) expressed in HEK293 cells assessed as efficacy incubated for 6 mins by thallium flux assay relative to VU0466551
Assay data:40 Tested
SummaryPubMed CitationRelated BioAssays by Target
Activation of GIRK1/4 channel (unknown origin) expressed in HEK293 cells incubated for 6 mins by thallium flux assay
Assay data:23 Active, 12 Activity ≤ 1 µM, 42 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
TBD from US Patent US10202390: "Heteroaryl substituted aminopyridine compounds"
Assay data:28 Active, 28 Activity ≤ 1 µM, 28 Tested
Activation of human GIRK1/4 expressed in HEK293 cells co-expressing rat mGlu8 by thallium flux assay relative to control
Assay data:55 Tested
Activation of human GIRK1/4 expressed in HEK293 cells co-expressing rat mGlu8 by thallium flux assay
Assay data:36 Active, 21 Activity ≤ 1 µM, 55 Tested
Inhibition of Kir3.4 (unknown origin)
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition GIRK1/4 (unknown origin)
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
Inhibition of GIRK-1/4 channel (unknown origin) expressed in HEK293 cells by automated patch clamp method
Assay data:6 Active, 7 Tested
Inhibition of GIRK-1/4 channel (unknown origin) expressed in HEK293 cells at 10 uM by automated patch clamp method relative to control
Assay data:16 Tested
Inhibition of GIRK-1/4 channel (unknown origin) expressed in HEK293 cells at 1 uM by automated patch clamp method relative to control
Assay data:17 Tested
Inhibition of human Kir3.1/3.4 at 10 uM by patch clamp method relative to control
Assay data:1 Tested
Human Kir3.4 (Inwardly rectifying potassium channels)
Assay data:4 Active, 4 Tested
Inhibition of GTPgammaS-induced activation of GIRK1/4 (unknown origin) expressed in HEK293 cells assessed as decrease in channel current after 2 mins at -40 mV holding potential by automated patch-clamp electrophysiology assay
Assay data:5 Active, 5 Tested
Inhibition of GTPgammaS-induced activation of GIRK1/4 (unknown origin) expressed in HEK293 cells assessed as decrease in channel current at 10 uM after 2 mins at -40 mV holding potential by automated patch-clamp electrophysiology assay
Assay data:21 Tested
Inhibition of GTPgammaS-induced activation of GIRK1/4 (unknown origin) expressed in HEK293 cells assessed as decrease in channel current at 1 uM after 2 mins at -40 mV holding potential by automated patch-clamp electrophysiology assay
Inhibition of full-length human GIRK1/4 expresssed in CHO-K1 cells under holding potential at -80 mV by patch clamp method
Assay data:34 Active, 22 Activity ≤ 1 µM, 34 Tested
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced TNF-alpha response in human macrophages_Secondary screen TNF readout
Assay data:731 Active, 3462 Tested
SummaryRelated BioAssays by Same Project
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced TNF-alpha response in human macrophages_Primary screen TNF readout
Assay data:2853 Active, 18113 Tested
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