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Potentiation of human KCa2.3 expressed in HEK293 cells at -90 mV holding potential measured at 1 to 2 days by patch clamp electrophysiology
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Potentiation of human KCa2.3 expressed in HEK293 cells at -90 mV holding potential measured at 1 to 2 days by patch clamp electrophysiology relative to calcium
Voltage-Clamp Assay from US Patent US9675591: "Methods for treating seizure disorders and pain"
Assay data:1 Active, 1 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
SK+Ca channel CEREP ligand profiling
Assay data:1 Tested
SummaryRelated BioAssays by Target
SKCa channel CEREP ligand profiling
K+ channel (Ca2+-dependent) CEREP ligand profiling
K+ channel (Ca2+ - dependent) Ligand binding assay
SK+ channel CEREP ligand profiling
Inhibition of SK3 (unknown origin) assessed as reduction in SK3 expression in presence of proteinase K
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of SK3-dependent cell migration in human MDA-MB-435 cells assessed as ratio of total cells migrating by matrigel invasion method relative to control
Assay data:3 Tested
Inhibition of recombinant human SK3 expressed in HEK293T cells assessed as reduction in channel current with holding potential 0 mV and ramp voltage from -100 to 100 mV by whole cell patch clamp method
Assay data:3 Active, 2 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 3 Tested
Inhibition of recombinant human SK3 expressed in HEK293T cells assessed as ratio of amplitude of outward current blocked in presence and absence of compound at 1 nM and holding potential at 0 mV and ramp voltage from -100 to 100 mV by whole cell patch clamp method relative to control
Inhibition of recombinant human SK3 expressed in HEK293T cells at 100 nM and holding potential at 0 mV and ramp voltage from -100 to 100 mV by whole cell patch clamp method relative to control
Inhibition of recombinant human SK3 expressed in HEK293T cells at 10 nM and holding potential at 0 mV and ramp voltage from -100 to 100 mV by whole cell patch clamp method relative to control
Assay data:13 Tested
Inhibition of recombinant human SK3 expressed in HEK293T cells assessed as decrease in intracellular calcium level at membrane potential -120 mV for 50 ms followed by 400 ms voltage ramp to 60 mV by whole cell patch clamp method
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
Inhibition of SK3 (unknown origin) expressed in HEK293 cells assessed as reduction in channel current at 10 uM with 0 mV holding potential in presence of -apamin by patch clamp electrophysiological method
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of SK3 (unknown origin) expressed in HEK293 cells assessed as reduction in channel current at 2 uM with 0 mV holding potential in presence of -apamin by patch clamp electrophysiological method
Inhibition of SK3 (unknown origin) expressed in HEK293 cells assessed as reduction in channel current at 10 uM with 0 mV holding potential measured within 100 secs by patch clamp electrophysiological method relative to control
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