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Alexa Plus Fret from US Patent US11530244: "Cyclic polypeptides for PCSK9 inhibition"
Assay data:90 Active, 51 Activity ≤ 1 µM, 111 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Alexa Fret from US Patent US11530244: "Cyclic polypeptides for PCSK9 inhibition"
Assay data:233 Active, 176 Activity ≤ 1 µM, 311 Tested
Identification of Polypeptides that Bind Specifically to Human PCSK9 and Inhibit Interaction Between Human PCSK9 and Human LDLR from US Patent US11530244: "Cyclic polypeptides for PCSK9 inhibition"
Assay data:180 Active, 169 Activity ≤ 1 µM, 250 Tested
Inhibition of PCSK9 (unknown origin) interaction with LDLR (unknown origin) by ELISA
Assay data:19 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of avi-tagged-biotinylated human PCSK9 interaction with His-tagged human LDLR EGFa domain by LANCE Ulight Streptavidin based TR-FRET assay
Assay data:32 Active, 28 Activity ≤ 1 µM, 59 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of recombinant human His-tagged PCSK9 interaction with recombinant LDLR AB domain (unknown origin) at higher concentration measured after 3 hrs by horseradish peroxidase-coupled TMB substrate based spectrophotometry relative to control
Assay data:4 Tested
Inhibition of recombinant human His-tagged PCSK9 interaction with recombinant LDLR AB domain (unknown origin) measured after 3 hrs by horseradish peroxidase-coupled TMB substrate based spectrophotometry
Assay data:14 Active, 7 Activity ≤ 1 µM, 21 Tested
Inhibition of PCSK9 (unknown origin) interaction with LDLR expressed in human HepG2 cells assessed as increase in LDL uptake level measured after 24 hrs by LDL-Dylight 550 dye based fluorescence assay
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of PCSK9 (unknown origin) interaction with LDLR expressed in human HepG2 cells assessed as LDL uptake level at 10 uM measured after 2 hrs by LDL-Dylight 550 dye based fluorescence assay (Rvb = 34.8 to 67%)
Assay data:1 Tested
Inhibition of PCSK9 (unknown origin) interaction with LDLR expressed in human HepG2 cells assessed as LDL uptake level at 0.1 uM measured after 2 hrs by LDL-Dylight 550 dye based fluorescence assay (Rvb = 34.8 to 67%)
Inhibition of PCSK9 (unknown origin) interaction with LDLR expressed in human HepG2 cells assessed as increase in LDL uptake level at 10 uM measured after 2 hrs by LDL-Dylight 550 dye based fluorescence assay
Inhibition of PCSK9 (unknown origin) interaction with LDLR expressed in human HepG2 cells assessed as LDL uptake level at 1 uM measured after 2 hrs by LDL-Dylight 550 dye based fluorescence assay (Rvb = 34.8 to 67%)
Assay data:2 Tested
Inhibition of PCSK9 (unknown origin) interaction with LDLR expressed in human HepG2 cells assessed as increase LDLR level on cell membrane measured after 2 hrs by in-cell Western analysis
Inhibition of PCSK9 (unknown origin) interaction with LDLR expressed in human HepG2 cells assessed as LDLR level on cell membrane at 10 uM measured after 2 hrs by in-cell Western analysis (Rvb = 30.5 to 47.2%)
Inhibition of PCSK9 (unknown origin) interaction with LDLR expressed in human HepG2 cells assessed as LDLR level on cell membrane at 0.1 uM measured after 2 hrs by in-cell Western analysis (Rvb = 30.5 to 47.2%)
Inhibition of PCSK9 (unknown origin) interaction with LDLR expressed in human HepG2 cells assessed as increase LDLR level on cell membrane at 10 uM measured after 2 hrs by in-cell Western analysis
Inhibition of recombinant His-tagged PCSK9 (unknown origin) binding to recombinant LDRR AB domain (unknown origin) at 100 uM measured after 2 hrs by ELISA relative to control
Inhibition of recombinant His-tagged PCSK9 (unknown origin) binding to recombinant LDRR AB domain (unknown origin) at 10 uM measured after 2 hrs by ELISA
Inhibition of recombinant His-tagged PCSK9 (unknown origin) binding to recombinant LDRR AB domain (unknown origin) measured after 2 hrs by ELISA
Assay data:3 Active, 5 Tested
Inhibition of PCSK9 (unknown origin) interaction with LDLR expressed in human HepG2 cells assessed as LDLR level on cell membrane at 1 uM measured after 2 hrs by in-cell Western analysis (Rvb = 30.5 to 47.2%)
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