BioAssay by Target (List) for Gene (Select 3984) - PubChem BioAssay - NCBI

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Select item 19410761.

Inhibition of human recombinant LIMK1

Source:: ChEMBL

Protein Target:: LIM domain kinase 1

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1941076

Summary Related BioAssays by Target

Select item 19410612.

Inhibition of LIMK1 (unknown origin) phosphorylation of cofilin

Source:: ChEMBL

Protein Target:: LIM domain kinase 1

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1941061

Summary Related BioAssays by Target

Select item 19410573.

Inhibition of LIMK1 (unknown origin)

Source:: ChEMBL

Protein Target:: LIM domain kinase 1

Assay data:7 Active, 7 Activity ≤ 1 µM, 8 Tested

AID:: 1941057

Summary Related BioAssays by Target

Select item 19410554.

Inhibition of human recombinant LIMK1 in presence of ATP cofilin as substrate at 25 uM

Source:: ChEMBL

Protein Target:: LIM domain kinase 1

Assay data:5 Active, 5 Activity ≤ 1 µM, 5 Tested

AID:: 1941055

Summary Related BioAssays by Target

Select item 19410485.

Inhibition of human LIMK1 (321 to 647 residues) expressed in Sf9 cells using dextrin as substrate incubated for 30 mins by micro-scintillation fluid method

Source:: ChEMBL

Protein Target:: LIM domain kinase 1

Assay data:15 Active, 2 Activity ≤ 1 nM, 14 Activity ≤ 1 µM, 19 Tested

AID:: 1941048

Summary Related BioAssays by Target

Select item 19198166.

In Vitro Assay from US Patent US20230312576: "4-(7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)-3,6-DIHYDROPYRIDINE-1-(2H)-CARBOXAMIDE DERIVATIVES AS LIMK AND/OR ROCK KINASES INHIBITORS FOR USE IN THE TREATMENT OF CANCER"

Source:: BindingDB

Protein Targets:: LIM domain kinase 1; ...
Total:: 2

Assay data:118 Active, 114 Activity ≤ 1 µM, 118 Tested

AID:: 1919816

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19154287.

Selectivity interaction (DSF assay) EUB0000285b LIMK1

Source:: ChEMBL

Protein Target:: LIM domain kinase 1

Assay data:1 Tested

AID:: 1915428

Summary Related BioAssays by Target

Select item 19154178.

Selectivity interaction (ScanMAX (DiscoverX, competition-binding assay)) EUB0000232b LIMK1

Source:: ChEMBL

Protein Target:: LIM domain kinase 1

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1915417

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19154169.

Selectivity interaction (Kinobead pulldown assay ) EUB0000232b LIMK1

Source:: ChEMBL

Protein Target:: LIM domain kinase 1

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1915416

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 191541510.

Selectivity interaction (DSF assay) EUB0000232b LIMK1

Source:: ChEMBL

Protein Target:: LIM domain kinase 1

Assay data:1 Tested

AID:: 1915415

Summary Related BioAssays by Target

Select item 191336611.

Affinity Biochemical interaction (RapidFire MS assay) EUB0000285b LIMK1

Source:: ChEMBL

Protein Target:: LIM domain kinase 1

Assay data:1 Tested

AID:: 1913366

Summary Related BioAssays by Target

Select item 191336412.

Affinity Biochemical interaction (RapidFire MS assay) EUB0000232b LIMK1

Source:: ChEMBL

Protein Target:: LIM domain kinase 1

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1913364

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 191305313.

Affinity On-target Cellular interaction (NanoBRET assay (HEK293T cells)) EUB0000285b LIMK1

Source:: ChEMBL

Protein Target:: LIM domain kinase 1

Assay data:1 Tested

AID:: 1913053

Summary Related BioAssays by Target

Select item 191305114.

Affinity On-target Cellular interaction (NanoBRET assay (HEK293T cells)) EUB0000232b LIMK1

Source:: ChEMBL

Protein Target:: LIM domain kinase 1

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1913051

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 188951515.

Inhibition of LIMK1 (unknown origin)

Source:: ChEMBL

Protein Target:: LIM domain kinase 1

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1889515

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 188901616.

Inhibition of LIMK1 (unknown origin) at 1.0 uM relative to control

Source:: ChEMBL

Protein Target:: LIM domain kinase 1

Assay data:1 Tested

AID:: 1889016

Summary PubMed Citation Related BioAssays by Target

Select item 188393917.

Inhibition of LIMK1 (unknown origin) at 1 uM relative to control

Source:: ChEMBL

Protein Target:: LIM domain kinase 1

Assay data:1 Tested

AID:: 1883939

Summary PubMed Citation Related BioAssays by Target

Select item 186461118.

Inhibition of human LIMK1 at 1 uM relative to control

Source:: ChEMBL

Protein Target:: LIM domain kinase 1

Assay data:1 Tested

AID:: 1864611

Summary PubMed Citation Related BioAssays by Target

Select item 185747619.

Inhibition of LIMK1/LIMK2 in human SH-SY5Y cells assessed as effect on phospho cofilin serine 3 phosphorylation incubated for 2 hr by AlphaLISA SureFire assay

Source:: ChEMBL

Protein Targets:: LIM domain kinase 1; ...
Total:: 2

Assay data:11 Active, 11 Activity ≤ 1 µM, 17 Tested

AID:: 1857476

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 185747420.

Inhibition of recombinant LIMK1(unknown origin) expressed in HEK293 cells using NanoGlo substrate incubated for 2 hrs followed by substrate addition by NanoBRET assay

Source:: ChEMBL

Protein Target:: LIM domain kinase 1

Assay data:12 Active, 11 Activity ≤ 1 µM, 17 Tested

AID:: 1857474

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

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Target

Proteins (3)
BioAssays with protein sequences specified as targets
RNAi Target, Active (8)
BioAssays with gene sequences specified as RNAi targets and the activity is active

BioActivity

Active Compounds (70)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (5)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (61)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Summary (1)
BioAssays summarizing information from multiple assays for validated chemical probes or small molecule leads
Confirmatory (80)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
Primary Screening (41)
Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose
Chemical Screens (203)
BioAssays reporting BioActivity of chemical reagents
RNAi Screens (47)
BioAssays reporting BioActivity of RNAi reagents

Assay Project (1)
BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

Depositor Category

Literature Extraction (169)
BioAssays extracted from the literature
NIH MLP (2)
BioAssays deposited by the NIH Molecular Libraries Program
Other (78)
BioAssays deposited by other experimentalists

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