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Invivo inhibition of human Delta 5 desaturase in atherosclerosis mouse model at 3 mg/kg, po relative to control
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Invivo inhibition of human Delta 5 desaturase in C57BL/6J mouse at 3 mg/kg, po relative to control
Inhibition of human Delta 5 desaturase (unknown origin) expressed in human HepG2 cells
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of Delta-5-desaturase (unknown origin) expressed in HEK2936E cell membrane incubated for 1 hr by DGLA-CoA and Arachidonyl-CoA mass spectrometric assay
Assay data:6 Active, 6 Activity ≤ 1 µM, 6 Tested
Binding affinity to recombinant wild type D5D (unknown origin) expressed in baculovirus at 5 to 25 nM after 150 mins by liquid scintillation counting
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of D5D in human HepG2 cells using [14C]DGLA as substrate assessed as suppression of [14C]AA production at 10 uM preincubated for 3 hrs followed by compound washout and addition of substrate measured after 4 hrs by liquid scintillation counting
Ratio of inhibition of D5D in human HepG2 cells preincubated for 30 mins followed by [14C]DGLA substrate addition measured after 3 hrs to inhibition of D5D in human HepG2 cells assessed as inhibition of [14C]AA production preincubated for 3 hrs followed by compound washout and addition of [14C]DGLA substrate measured after 4 hrs
Inhibition of D5D in human HepG2 cells using [14C]DGLA as substrate preincubated for 30 mins followed by substrate addition measured after 3 hrs
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
Inhibition of D5D in human HepG2 cells assessed as [14C]AA formation from [14C]DGLA preincubated for 30 mins followed by [14C]eicosatrienoic acid addition measured after 3 hrs by TLC analysis
Assay data:13 Active, 1 Activity ≤ 1 nM, 12 Activity ≤ 1 µM, 19 Tested
Inhibition of delta-5 fatty acid desaturase (unknown origin)
Assay data:2 Tested
Inhibition of liver delta-5 desaturase (unknown origin)
Assay data:25 Active, 25 Activity ≤ 1 µM, 26 Tested
Inhibition of liver delta-5 desaturase (unknown origin) at 1 uM
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced TNF-alpha response in human macrophages_Primary screen TNF readout
Assay data:2853 Active, 18113 Tested
SummaryRelated BioAssays by Same Project
A screen to identify synthetic lethal interactions with E-cadherin in an MCF10A isogenic cell line
Assay data:2442 Active, 18052 Tested
SummaryPubMed Citation
A screen to identify genes that regulate lymphatic endothelial cell migration - Primary Screen
Assay data:1034 Active, 18120 Tested
SummaryRelated BioAssays by Depositor
Identification of proteins required for the processing of the EWS-FLI1 nascent transcript
Assay data:59220 Tested
A whole genome RNAi screen highlights components of the ER/Golgi as a prominent source of resistance to immunotoxin-mediated cytotoxicity
Assay data:555 Active, 64752 Tested
Inhibition of human delta-5 desaturase at 10 uM
Assay data:27 Tested
Assay data:28 Tested
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