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Affinity Biochemical interaction (RapidFire/MS assay ) EUB0000315b MGAT2
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Affinity On-target Cellular interaction (Cell-based assay) EUB0000315b MGAT2
Inhibition of recombinant human MGAT2 expressed in Sf9 cell membrane assessed as inhibition of triglyceride synthesis at 10 uM for 1 hr by LC-MS-based mass spectrophotometric analysis
Assay data:5 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of human MGAT2 using [1-14C]decanoyl-CoA and 1-decanoyl-rac-glycerol as substrates assessed as incorporation of [1-14C]decanoyl into diacylglycerol preincubated for 30 mins followed by substrate addition and measured after 30 to 90 mins by scintillation counting method
Assay data:2 Tested
Inhibitory Activity from US Patent US11198695: "Fused ring derivative having MGAT-2 inhibitory activity"
Assay data:573 Active, 24 Activity ≤ 1 nM, 573 Activity ≤ 1 µM, 573 Tested
LCMS Assay from US Patent US9365558: "Dihydropyridinone MGAT2 inhibitors"
Assay data:94 Active, 2 Activity ≤ 1 nM, 94 Activity ≤ 1 µM, 94 Tested
MGAT LCMS Assay from US Patent US9187424: "Aryl dihydropyridinones and piperidinone MGAT2 inhibitors"
Assay data:261 Active, 6 Activity ≤ 1 nM, 240 Activity ≤ 1 µM, 262 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
MGAT SPA Assay from US Patent US9187424: "Aryl dihydropyridinones and piperidinone MGAT2 inhibitors"
Assay data:125 Active, 87 Activity ≤ 1 µM, 127 Tested
Measurement of Human MGAT2 Inhibitory Activity from US Patent US10335401: "Non-aromatic heterocyclic derivative having MGAT2 inhibitory activity"
Assay data:94 Active, 4 Activity ≤ 1 nM, 94 Activity ≤ 1 µM, 94 Tested
MGAT LCMS Assay from US Patent US10329273: "Tetrazolone-substituted dihydropyridinone MGAT2 inhibitors"
Assay data:22 Active, 22 Activity ≤ 1 µM, 22 Tested
LCMS Assay from US Patent US9822074: "Dihydropyridinone MGAT2 inhibitors"
MGAT LCMS Assay from US Patent US10093650: "Tetrazolone-substituted dihydropyridinone MGAT2 inhibitors"
Assay data:23 Active, 23 Activity ≤ 1 µM, 23 Tested
MGAT2 Human Assay from US Patent US10065945: "Isoquinoline derivatives as MGAT2 inhibitors"
Assay data:9 Active, 9 Activity ≤ 1 µM, 9 Tested
MGAT LCMS Assay from US Patent US9701672: "Dihydropyridinone MGAT2 inhibitors for use in the treatment of metabolic disorders"
Assay data:72 Active, 4 Activity ≤ 1 nM, 72 Activity ≤ 1 µM, 73 Tested
Cell-based assay
RapidFire/MS assay (human MGAT2)
Assay data:1 Active, 1 Activity ≤ 1 µM, 2 Tested
Inhibition of human recombinant MGAT2 expressed in Sf9 cell membrane using 2-monooleglycerol and [H3]-oleoyl-CoA as substrates incubated for 20 mins by scintillation proximity assay
Assay data:55 Active, 53 Activity ≤ 1 µM, 59 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of recombinant human MGAT2
Assay data:15 Active, 6 Activity ≤ 1 nM, 15 Activity ≤ 1 µM, 15 Tested
Inhibition of recombinant human MGAT2 expressed in sf9 cells using 2-monooleoyl glycerol/[14C]-oleoyl CoA as substrate by microscintillation counting method
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
Inhibition of recombinant human MGAT2 using 2-monooleoyl glycerol/[1-14C]-oleoyl CoA as substrate after 30 mins by liquid scintillation counting method
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
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