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Inhibition of recombinant SUMO-fused MLL1/ASH2L/RBBP5/WDR5 complex histone methyltransferase activity (unknown origin) expressed in Escherichia coli BL21 (DE3) using 10-mer histone H3 peptide as substrate and [3H]-S-adenosyl methionine as cofactor after 2 hrs by scintillation counting method
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of MLL1-WDR5 protein-protein interaction in human MV4-11 cells harboring MLL-AF4 fusion protein assessed as inhibition of Hoxa9 gene expression at 2.5 uM after 7 days by RT-PCR method relative to control
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of MLL1-WDR5 protein-protein interaction in human MV4-11 cells harboring MLL-AF4 fusion protein assessed as inhibition of Meis-1 gene expression after 7 days by RT-PCR method
Inhibition of MLL1-WDR5 protein-protein interaction in human MV4-11 cells harboring MLL-AF4 fusion protein assessed as inhibition of Hoxa9 gene expression after 7 days by RT-PCR method
Inhibition of MLL1-WDR5 protein-protein interaction in human MV4-11 cells harboring MLL-AF4 fusion protein assessed as inhibition of MLL1 histone methyltransferase activity by measuring reduction in H3K4me2 level at 10 uM after 7 days by Western blot method
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of MLL1-WDR5 protein-protein interaction in human MV4-11 cells harboring MLL-AF4 fusion protein assessed as inhibition of MLL1 histone methyltransferase activity by measuring reduction in H3K4me2 level after 7 days by Western blot method
Inhibition of MLL1-WDR5 protein-protein interaction in human MV4-11 cells harboring MLL-AF4 fusion protein assessed as inhibition of MLL1 histone methyltransferase activity by measuring reduction in H3K4me1 level at 10 uM after 7 days by Western blot method
Inhibition of MLL1-WDR5 protein-protein interaction in human MV4-11 cells harboring MLL-AF4 fusion protein assessed as inhibition of MLL1 histone methyltransferase activity by measuring reduction in H3K4me1 level at 5 uM after 7 days by Western blot method
Inhibition of recombinant MLL1/ASH2L/RBBP5/WDR5 complex histone methyltransferase activity (unknown origin) by AlphaScreen assay
Assay data:4 Active, 3 Activity ≤ 1 µM, 4 Tested
Inhibition of recombinant MLL1/ASH2L/RBBP5/WDR5 complex histone methyltransferase activity (unknown origin) at 30 uM by AlphaScreen assay relative to control
Assay data:3 Tested
Inhibition of MLL1-WDR5 protein-protein interaction in human MV4-11 cells harboring MLL-AF4 fusion protein assessed as inhibition of Hoxa9 gene expression at 10 uM after 7 days by RT-PCR method relative to control
Inhibition of His-SUMO-fused MLL1 (3762 to 3969 residues) interaction with His-SUMO-fused ASH2L/RBBP5/WDR5 (23 to 334 residues) (unknown origin) expressed in Escherichia coli BL21 DE3 pLyss codon (+) assessed as decrease in methylation of Lys4 residue of histone H3 10-residue peptide using [3H]-S-adenosylmethionine as methyl donor after 2 hrs by scintillation counting method
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of His-SUMO-fused MLL1 (3762 to 3969 residues) interaction with His-SUMO-fused ASH2L/RBBP5/WDR5 (23 to 334 residues) (unknown origin) expressed in Escherichia coli BL21 DE3 pLyss codon (+) assessed as decrease in methylation of Lys4 residue of histone H3 10-residue peptide using [3H]-S-adenosylmethionine as methyl donor preincubated for 2 to 5 mins with ASH2L/RBBP5/WDR5 followed by MLL1 addition measured after 30 mins by scintillation counting method
Inhibition of recombinant MLL1 (unknown origin) interaction with recombinant ASH2L/RBBP5/WDR5 (unknown origin) assessed as decrease in histone methylation after 60 mins by Alpha Screen assay
Assay data:3 Active, 1 Activity ≤ 1 µM, 3 Tested
Inhibition of MLL1 (unknown origin) at 50 uM using biotin-labeled peptide as substrate and [3H]-SAM measured after 1 hr by scintillation proximity assay
Inhibition of MLL1 (unknown origin) at 1 to 50 uM by scintillation proximity assay
Inhibition of SUMO-His-tagged MLL1 activity (unknown origin) expressed in Escherichia coli BL21(DE3) pLysS cells using histone H3 as substrate by scintillation counting method in presence of [3H]SAM
Inhibition of human MLL1 at 10 and 50 uM
Inhibition of menin-MLL interaction (unknown origin) after 1 hr by fluorescence polarization assay
Assay data:37 Active, 37 Activity ≤ 1 µM, 37 Tested
Inhibition of menin-MLL (unknown origin) interaction
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