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Biochemical Assay for Modulation (Inhibition/Activation) of GCN2 from US Patent US20240083897: "GCN2 MODULATING COMPOUNDS AND USES THEREOF"
Assay data:203 Active, 208 Activity ≤ 1 µM, 208 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Biochemical Assay for GCN2 from US Patent US11912668: "GCN2 and perk kinase inhibitors and methods of use thereof"
Assay data:175 Active, 150 Activity ≤ 1 µM, 175 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Biochemical Assay from US Patent US20240025884: "COMPOUNDS AS GCN2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF"
Assay data:498 Active, 503 Activity ≤ 1 µM, 503 Tested
Biochemical Assay for GCN2 from US Patent US20230382915: "GCN2 AND PERK KINASE INHIBITORS AND METHODS OF USE THEREOF"
Assay data:30 Active, 24 Activity ≤ 1 µM, 30 Tested
Selectivity interaction (KinomeScan (DiscoverX)) EUB0000333a EIF2AK4
Assay data:1 Tested
SummaryRelated BioAssays by Target
Selectivity interaction (KinomeScan (DiscoverX)) EUB0000296b EIF2AK4
Selectivity interaction (KinomeScan (DiscoverX)) EUB0000301b EIF2AK4
Selectivity interaction (KinomeScan (DiscoverX)) EUB0000702a EIF2AK4
Inhibition of GCN2 in human SK-OV-3 cells assessed as reduction in phosphorylation of eIF2alpha in presence of human serum by cellular assay
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of GCN2 in human SK-OV-3 cells assessed as reduction in phosphorylation of eIF2alpha by cellular assay
Assay data:22 Active, 22 Activity ≤ 1 µM, 36 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of GCN2 (unknown origin)
Assay data:41 Active, 46 Activity ≤ 1 µM, 46 Tested
GCN2(Kin.Dom.2,S808G) DiscoveRx kinase panel
GCN2(h) Kinase panel
Inhibition of human recombinant GCN2 assessed as reduction in substrate phosphorylation at 50 to 500 nM using ATP and Ulight-CKKSRGDYMTMQIG (IRS-1) incubated for 60 min by LANCE detection method
SummaryPubMed CitationRelated BioAssays by Target
Enzyme Inhibition Assay from US Patent US10793563: "GCN2 inhibitors and uses thereof"
Assay data:502 Active, 502 Activity ≤ 1 µM, 502 Tested
GCN2 Enzyme Inhibition (ATP 300 uM) from US Patent US20230271939: "4-ETHYNYLPYRIDINE DERIVATIVES USEFUL AS GCN2 INHIBITORS"
Assay data:42 Active, 12 Activity ≤ 1 nM, 42 Activity ≤ 1 µM, 42 Tested
GCN2 Enzyme Inhibition (ATP 10 uM) from US Patent US20230271939: "4-ETHYNYLPYRIDINE DERIVATIVES USEFUL AS GCN2 INHIBITORS"
Assay data:19 Active, 2 Activity ≤ 1 nM, 19 Activity ≤ 1 µM, 19 Tested
KinomeScan assay: inhibition of GCN2(Kin.Dom.2,S808G)
Assay data:1 Active, 108 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
GCN2(EIK4PHK1) Takeda global kinase panel
Assay data:1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, activity ≤ 1 µMRelated BioAssays by Target
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