Warning: The NCBI web site requires JavaScript to function. more...
An official website of the United States government
The .gov means it's official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.
The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.
Enzymatic ATM Assay from US Patent US20230348462: "IMIDAZO[4,5-C]QUINOLINE COMPOUNDS AND THEIR USE AS ATM KINASE INHIBITORS"
Assay data:27 Active, 17 Activity ≤ 1 nM, 27 Activity ≤ 1 µM, 27 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Kinase Assay from US Patent US11787781: "Inhibiting ataxia telangiectasia and RAD3-related protein (ATR)"
Assay data:4 Active, 1 Activity ≤ 1 µM, 7 Tested
Assay of ATR Kinase Activity from US Patent US20230271968: "PYRAZOLOPYRIMIDINE COMPOUND USED AS ATR KINASE INHIBITOR"
Assay data:24 Active, 24 Activity ≤ 1 µM, 24 Tested
Biological Assay from US Patent US11685734: "ATM kinase inhibitors and compositions and methods of use thereof"
Assay data:121 Active, 1 Activity ≤ 1 nM, 121 Activity ≤ 1 µM, 121 Tested
ATM Kinase Assay from US Patent US11608338: "Imidazolonylquinolines and the use thereof as ATM kinase inhibitors"
Assay data:138 Active, 70 Activity ≤ 1 nM, 138 Activity ≤ 1 µM, 138 Tested
Inhibition of ATM in human A549 cells assessed as reduction in etoposide-stimulated KAP1 phosphorylation by In-Cell-Western assay
Assay data:8 Active, 5 Activity ≤ 1 nM, 8 Activity ≤ 1 µM, 8 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of ATM (unknown origin) by FRET assay
Assay data:35 Active, 16 Activity ≤ 1 nM, 34 Activity ≤ 1 µM, 35 Tested
Inhibition of ATM (unknown origin) assessed as decrease in phosphorylation of p21 at 25 uM measured in presence of 50 nM AZD0156 by Western blot analysis
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of ATM (unknown origin) assessed as decrease in phosphorylation of p21 at 25 uM measured in presence of 5 uM KU60019 by Western blot analysis
Inhibition of ATM (unknown origin) assessed as decrease in phosphorylation of p21 at 25 uM measured in presence of 1 uM KU60019 by Western blot analysis
Inhibition of ATM (unknown origin) assessed as decrease in phosphorylation of KAP1 at 25 uM measured in presence of 50 nM AZD0156 by Western blot analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of ATM (unknown origin) assessed as decrease in phosphorylation of KAP1 at 25 uM measured in presence of 1 to 5 uM KU60019 by Western blot analysis
Inhibition of ATM (unknown origin) assessed as decrease in phosphorylation of ATM at 25 uM measured in presence of 50 nM AZD0156 by Western blot analysis
Inhibition of ATM (unknown origin) assessed as decrease in phosphorylation of ATM at 25 uM measured in presence of 1 to 5 uM KU60019 by Western blot analysis
Binding affinity towards ATM (unknown origin) assessed as increase in thermal stability of ATM at 30 uM measured by thermal shift assay
Assay data:2 Active, 2 Tested
Inhibition of ATM in human MCF7 cells assessed as increase in pKAP1 level at 12.5 to 18 uM measured by western blot analysis
Inhibition of ATM in human MCF7 cells assessed as increase in pATM level at 12.5 to 18 uM measured by western blot analysis
Activation of ATM in human MCF7 cells assessed as increase in pKAP1 level at 30 uM in presence of 25 uM etoposide measured by western blot analysis
Activation of ATM in human MCF7 cells assessed as increase in pKAP1 level at 30 uM measured by western blot analysis
Activation of ATM in human MCF7 cells assessed as increase in pATM level at 30 uM in presence of 25 uM etoposide measured by western blot analysis
Filters: Manage Filters
Your browsing activity is empty.
Activity recording is turned off.
Turn recording back on