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Affinity of [125I][D-Tyr0]-NMB to human Neuromedin B receptor expressed in HEK293 cells
Assay data:21 Active, 7 Activity ≤ 1 µM, 28 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Ratio of benzodiazepine IC50 to compound IC50 for antagonist activity at human neuromedin B receptor transfected in HEK293 cells assessed as inhibition of 1 mM neuromedin B-induced myo-[3H]inositol phosphate accumulation
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Antagonist activity at human neuromedin B receptor transfected in HEK293 cells assessed as inhibition of 1 nM neuromedin B-induced myo-[3H]inositol phosphate accumulation after 60 mins by scintillation proximity assay
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
Ratio of benzodiazepine IC50 to compound IC50 for human neuromedin B receptor transfected in HEK293 cells
Displacement of [125I]-(D-Tyr0)NMB from human neuromedin B receptor transfected in HEK293 cells
Assay data:34 Active, 18 Activity ≤ 1 µM, 34 Tested
Agonist activity at recombinant neuromedin B receptor expressed in baculovirus-transduced HEK293 cells assessed as intracellular calcium mobilization by FLIPR assay
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
Binding affinity to neuromedin B receptor
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of tachykinin receptor 3 expressed in human ileal carcinoid cells
Assay data:5 Active, 2 Activity ≤ 1 nM, 5 Activity ≤ 1 µM, 5 Tested
Inhibition of the NMB induced acidification response at human NMB receptor expressed in CHO cell
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition of the NMB evoked increases in chloride currents in xenopus oocytes expressing human NMB receptor
Binding affinity against human NMB receptor was determined
Binding affinity against [125 I][4Tyr]-bombesin labeled cloned human NMB receptor stably expressed in CHO cells
Assay data:20 Active, 19 Activity ≤ 1 µM, 20 Tested
Displacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]bombesin from human bombesin BB1 receptor expressed in NFAT-CHO cells after 2 hrs by liquid scintillation counting
Agonistic activity was determined against human Neuromedin B receptor transfected in HEK293 cells as accumulation levels of inositol phosphate
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Effective concentration required against nueromedin B receptor (NMB-R) in CHO cells by using FLIPR assay.
Assay data:32 Tested
Effective concentration required against nueromedin B receptor (NMB-R) in CHO cells by using FLIPR assay
Assay data:2 Active, 1 Activity ≤ 1 µM, 4 Tested
Binding affinity for human neuromedin B(hNMB) receptor expressed in CHO cells
Assay data:18 Active, 2 Activity ≤ 1 µM, 61 Tested
In vitro inhibition of bombesin-evoked increases in intracellular calcium level in CHO cells stably expressed human Bombesin receptor bb1; 1-6.6
In vitro inhibition of acidification responses to NMB at the human Bombesin receptor bb1 expressed in CHO cells; 1-17
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