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Inhibition of human nNOS using L-arginine as substrate assessed as reduction in NO production in the presence of NADPH by NO-hemoglobin capture assay
Assay data:11 Active, 9 Activity ≤ 1 µM, 11 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of human nNOS assessed as reduction in L-[3H]-citrulline level using L-[3H]-arginine as substrate incubated for 1 hr
Assay data:3 Active, 22 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of NOS (unknown origin)
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Enzyme Inhibition Assay from US Patent US10759791: "Mammalian and bacterial nitric oxide synthase inhibitors"
Assay data:24 Active, 21 Activity ≤ 1 µM, 24 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition Assay from US Patent US9212144: "2-aminoquinoline-based compounds for potent and selective neuronal nitric oxide synthase inhibition"
Assay data:13 Active, 12 Activity ≤ 1 µM, 16 Tested
Enzyme Inhibition Assay from US Patent US9090589: "Specific nNOS inhibitors for the therapy and prevention of human melanoma"
Assay data:8 Active, 8 Activity ≤ 1 µM, 9 Tested
Enzyme Assay from US Patent US8618286: "Benzoxazines, benzothiazines, and related compounds having NOS inhibitory activity"
Assay data:29 Active, 25 Activity ≤ 1 µM, 29 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Enzyme Assay from US Patent US8586620: "Substituted indole compounds having NOS inhibitory activity"
Assay data:49 Active, 18 Activity ≤ 1 µM, 52 Tested
Inhibition Assay from Article 10.1021/bi9007098: "Developing dual and specific inhibitors of dimethylarginine dimethylaminohydrolase-1 and nitric oxide synthase: toward a targeted polypharmacology to control nitric oxide."
Assay data:6 Active, 2 Activity ≤ 1 µM, 8 Tested
Inhibitory Assay from Article 10.1021/bi1013479: "Role of zinc in isoform-selective inhibitor binding to neuronal nitric oxide synthase ."
Assay data:6 Active, 5 Activity ≤ 1 µM, 6 Tested
NOS Enzyme Inhibition Assay from Article 10.1038/nchembio.115: "Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase."
Assay data:15 Active, 14 Activity ≤ 1 µM, 15 Tested
Cell-Based NOS Transient Transfection Assay from Article 10.1021/jm900173b: "Discovery of inducible nitric oxide synthase (iNOS) inhibitor development candidate KD7332, part 1: Identification of a novel, potent, and selective series of quinolinone iNOS dimerization inhibitors that are orally active in rodent pain models."
Assay data:36 Active, 31 Activity ≤ 1 µM, 41 Tested
Inhibition Assay from US Patent US9951014: "Mammalian and bacterial nitric oxide synthase inhibitors"
Assay data:35 Active, 32 Activity ≤ 1 µM, 35 Tested
Enzyme Assay from US Patent US9783500: "2-aminoquinoline-based compounds for potent and selective neuronal nitric oxide synthase inhibition"
Assay data:18 Active, 18 Activity ≤ 1 µM, 18 Tested
Inhibition Assay from US Patent US9732037: "2-aminopyridine-based selective neuronal nitric oxide synthase inhibitors"
Assay data:21 Active, 20 Activity ≤ 1 µM, 21 Tested
Caco-2 Assay from US Patent US9878996: "2-imidazolyl-pyrimidine scaffolds as potent and selective inhibitors of neuronal nitric oxide synthase"
Assay data:13 Active, 9 Activity ≤ 1 µM, 14 Tested
Inhibition of recombinant human nNOS assessed as maximum inhibition relative to control
Assay data:9 Tested
Inhibition of recombinant human nNOS
Inhibition of NOS (unknown origin) at 0.1 to 1 uM
Inhibition of human recombinant nNOS expressed in Escherichia coli assessed as reduction in L-[3H]-citrulline level using L-[3H]-arginine as substrate incubated for 30 min by ELISA
Assay data:8 Tested
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