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Inhibition of NPM/ALK phosphorylation in human KARPAS-299 cells at 1 to 10 uM by Western blotting analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of NPM-ALK in human SU-DHL-1 cells at 1mM relative to control
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Induction of NPM-ALK degradation in human KARPAS-299 cells assessed as reduction in NPM-ALK protein level at 1 uM measured after 24 hrs by Western blot analysis
Protac activity at CRBN/NPM-ALK in human KARPAS-299 cells assessed as induction of NPM-ALK fusion protein degradation at 1 uM incubated for 24 hrs followed by compound washout and measured after 24 hrs by Western blot analysis
Protac activity at CRBN/NPM-ALK in human KARPAS-299 cells assessed as induction of NPM-ALK fusion protein degradation at 2 uM preincubated with Alectinib for 4 hrs followed by compound addition and measured after 24 hrs by Western blot analysis
Protac activity at CRBN/NPM-ALK in human KARPAS-299 cells assessed as induction of NPM-ALK fusion protein degradation at 2 uM preincubated with pomalidomide for 4 hrs followed by compound addition and measured after 24 hrs by Western blot analysis
Protac activity at CRBN/NPM-ALK in human KARPAS-299 cells assessed as induction of NPM-ALK fusion protein degradation at 2 uM preincubated with proteasome inhibitor, carfilzomib for 4 hrs followed by compound addition and measured after 24 hrs by Western blot analysis
Protac activity at CRBN/NPM-ALK in human KARPAS-299 cells assessed as induction of NPM-ALK fusion protein degradation at 2 uM preincubated with NAE inhibitor, MLN4924 for 4 hrs followed by compound addition and measured after 24 hrs by Western blot analysis
Protac activity at CRBN/NPM-ALK in human KARPAS-299 cells assessed as induction of NPM-ALK fusion protein degradation at 2 uM measured after 0 to 24 hrs by Western blot analysis
Assay data:2 Tested
Protac activity at CRBN/NPM-ALK in human KARPAS-299 cells assessed as induction of NPM-ALK fusion protein degradation at 2 uM incubated for 24 hrs by Western blot analysis
Protac activity at CRBN/NPM-ALK in human KARPAS-299 cells assessed as induction of NPM-ALK fusion protein degradation incubated for 48 hrs by Western blot analysis
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Protac activity at CRBN/NPM-ALK in human KARPAS-299 cells assessed as induction of NPM-ALK fusion protein degradation at 0.1 uM incubated for 24 hrs by Western blot analysis
Assay data:6 Tested
Protac activity at CRBN/NPM-ALK in human KARPAS-299 cells assessed as induction of NPM-ALK fusion protein degradation at 1 uM incubated for 24 hrs by Western blot analysis
Assay data:5 Tested
Protac activity at CRBN/NPM-ALK in human KARPAS-299 cells assessed as induction of NPM-ALK fusion protein degradation at 0.1 uM incubated for 24 hrs by Western blot analysis relative to control
Assay data:7 Tested
Protac activity at CRBN/NPM-ALK in human KARPAS-299 cells assessed as induction of NPM-ALK fusion protein degradation at 1 uM incubated for 24 hrs by Western blot analysis relative to control
Assay data:8 Tested
Induction of NPM-ALK degradation in human SR cells at 0.1 to 50 nM by Western blot analysis
Inhibition of NPM-ALK (unknown origin) expressed in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 48 hrs by cell proliferation assay
Assay data:2 Active, 2 Activity ≤ 1 µM, 3 Tested
Inhibition of NMP-ALK (unknown origin) expressed in human KARPAS-299 cells assessed as reduction in cell growth
Assay data:9 Active, 5 Activity ≤ 1 µM, 9 Tested
Inhibition NMP-ALK (unknown origin)
Inhibition of NMP-ALK (unknown origin) expressed in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 2 to 3 days by Bright-Glo luciferase assay
Assay data:18 Active, 11 Activity ≤ 1 µM, 18 Tested
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