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Inverse agonist activity at Gal4-fused Nurr1 (unknown origin)
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by Target
Modulation of full length human Nurr1 expressed in PC12 cells co-transfected with luciferase reporter plasmid harboring NBRE response element assessed as decrease in luciferase activity at 1.95 to 125 uM incubated for 18 hrs by luciferase reporter gene assay
Assay data:2 Active, 2 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Modulation of full length human Nurr1 expressed in SKNBE(2) cells co-transfected with RXRalpha and luciferase reporter plasmid harboring NBRE response element assessed as increase in luciferase activity at 100 uM incubated for 18 hrs by luciferase reporter gene assay
Assay data:1 Active, 1 Tested
Modulation of full length human Nurr1 expressed in SKNBE(2) cells co-transfected with luciferase reporter plasmid harboring NBRE response element assessed as decrease in luciferase activity at 12.5 to 50 uM incubated for 18 hrs by luciferase reporter gene assay
Modulation of full length human Nurr1 expressed in PC12 cells co-transfected with RXRalpha and luciferase reporter plasmid harboring NBRE response element assessed as increase in luciferase activity incubated for 18 hrs by luciferase reporter-gene assay
Assay data:3 Tested
Inverse agonist activity at human Nurr1 LBD assessed as displacement of NCoR1 from Nurr1 after 2 hrs by HTRF assay
Assay data:1 Tested
Agonist activity at nuclear orphan receptor Nurr1 expressed in human BGC823 cells co-transfected with fused GAL4-Nurr1(LBD) assessed as transactivation after 12 hrs by transactivation assay
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