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Agonist activity at human kappa opioid receptor expressed in HEK293 cells assessed as inhibition of forskolin-induced cAMP production after 30 mins by HTRF assay
Assay data:6 Active, 1 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 6 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of KOR (unknown origin) at 1 uM relative to control
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of KOR (unknown origin) at 10 uM relative to control
Assay data:7 Tested
Antagonist activity against human recombinant opioid kappa receptor expressed in CHO cell membranes assessed as reduction in (-)-U50,488-induced response after 3 hrs by [35S]GTP-gamma-S binding assay
Assay data:16 Tested
Agonist activity against human recombinant opioid kappa receptor expressed in CHO cell membranes after 3 hrs by [35S]GTP-gamma-S binding assay relative to 500 nM (-)-U50,488
Assay data:18 Tested
Agonist activity against human recombinant opioid kappa receptor expressed in CHO cell membranes after 3 hrs by [35S]GTP-gamma-S binding assay
Assay data:5 Active, 5 Activity ≤ 1 µM, 18 Tested
Displacement of [3H]U69,593 from human recombinant opioid kappa receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting method
Assay data:26 Active, 23 Activity ≤ 1 µM, 27 Tested
Antagonist activity at kappa opioid receptor (unknown origin)
Assay data:3 Active, 3 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 3 Tested
Agonist activity at human kappa opioid receptor expressed in COS7 cells after 60 mins IP1 assay
Assay data:39 Active, 2 Activity ≤ 1 nM, 26 Activity ≤ 1 µM, 43 Tested
Displacement of [3H]U69,593 from human kappa opioid receptor expressed in HEK293 cells after 2 hrs by scintillation counting
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Agonist activity at human kappa opioid receptor expressed in CHO cells assessed as stimulation of [35S]-GTPgammaS binding relative to U69593
Assay data:2 Tested
Agonist activity at human kappa opioid receptor expressed in CHO cells assessed as stimulation of [35S]-GTPgammaS binding
Binding affinity to human kappa opioid receptor
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Antagonist activity at human kappa opioid receptor expressed in CHO cells assessed as inhibition of U69,593-stimulated [35S]GTPgammaS binding
Assay data:15 Active, 10 Activity ≤ 1 nM, 15 Activity ≤ 1 µM, 15 Tested
Binding affinity to human kappa opioid receptor expressed in CHO cells
Partial agonist activity at recombinant kappa-opioid receptor in human HEK293 cells by [35S]-GTP-gammaS binding assay relative to U69593
Agonist activity at human kappa opioid receptor expressed in HEK-293 cells assessed as stimulation of [35S]-GTPgammaS binding at 1 uM after 30 mins by liquid scintillation counting analysis
Agonist activity at human kappa opioid receptor expressed in HEK-293 cells assessed as stimulation of [35S]-GTPgammaS binding after 30 mins by liquid scintillation counting analysis
Assay data:20 Active, 20 Activity ≤ 1 µM, 22 Tested
Displacement of [3H]U69593 from human kappa opioid receptor expressed in HEK293 cells by scintillation counting
Assay data:1 Active, 1 Activity ≤ 1 µM, 8 Tested
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