BioAssay by Target (List) for Gene (Select 5153) - PubChem BioAssay - NCBI

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Select item 1589221.

Inhibition of Phosphodiesterase 1/5 (PDE1/5) from guinea pig trachea (not tested)

Source:: ChEMBL

Protein Targets:: Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A; ...
Total:: 4

Assay data:2 Tested

AID:: 158922

Summary PubMed Citation Related BioAssays by Target

Select item 2409572.

Inhibition of human phosphodiesterase 1

Source:: ChEMBL

Protein Targets:: Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A; ...
Total:: 3

Assay data:2 Active, 1 Activity ≤ 1 µM, 4 Tested

AID:: 240957

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 2408933.

Inhibitory concentration against Phosphodiesterase type 1

Source:: ChEMBL

Protein Targets:: Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A; ...
Total:: 3

Assay data:30 Active, 9 Activity ≤ 1 µM, 61 Tested

AID:: 240893

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 2407584.

Inhibition of human phosphodiesterase 1

Source:: ChEMBL

Protein Targets:: Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A; ...
Total:: 3

Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested

AID:: 240758

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 2407575.

Inhibition of phosphodiesterase 1

Source:: ChEMBL

Protein Targets:: Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A; ...
Total:: 3

Assay data:25 Active, 29 Activity ≤ 1 µM, 29 Tested

AID:: 240757

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 2382926.

Inhibition of human phosphodiesterase 1

Source:: ChEMBL

Protein Targets:: Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A; ...
Total:: 3

Assay data:1 Tested

AID:: 238292

Summary PubMed Citation Related BioAssays by Target

Select item 2353367.

Selectivity ratio for Phosphodiesterase 1 and Phosphodiesterase 5

Source:: ChEMBL

Protein Targets:: Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A; ...
Total:: 4

Assay data:1 Tested

AID:: 235336

Summary PubMed Citation Related BioAssays by Target

Select item 2345398.

Realtive inhibition of PDE1 and PDE5

Source:: ChEMBL

Protein Targets:: Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A; ...
Total:: 4

Assay data:7 Tested

AID:: 234539

Summary PubMed Citation Related BioAssays by Target

Select item 2345379.

Relative inhibition of PDE1 and PDE5

Source:: ChEMBL

Protein Targets:: Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A; ...
Total:: 4

Assay data:3 Tested

AID:: 234537

Summary PubMed Citation Related BioAssays by Target

Select item 22989510.

Selectivity for human heart PDE-1 and human corpus cavernosum PDE-5

Source:: ChEMBL

Protein Targets:: Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A; ...
Total:: 4

Assay data:9 Tested

AID:: 229895

Summary PubMed Citation Related BioAssays by Target

Select item 22701711.

Relative inhibition of PDE1 (Phosphodiesterase) from human heart and PDE5 from human corpus cavernosum

Source:: ChEMBL

Protein Targets:: Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A; ...
Total:: 4

Assay data:5 Tested

AID:: 227017

Summary PubMed Citation Related BioAssays by Target

Select item 22017512.

Inhibition of [Ca(2+)]-calmodulin-dependent cGMP-phosphodiesterase 1 from porcine coronary arteries

Source:: ChEMBL

Protein Targets:: Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A; ...
Total:: 3

Assay data:3 Tested

AID:: 220175

Summary PubMed Citation Related BioAssays by Target

Select item 22017413.

Inhibition of [Ca(2+)]-calmodulin-dependent cGMP-phosphodiesterase 1 from porcine coronary arteries

Source:: ChEMBL

Protein Targets:: Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A; ...
Total:: 3

Assay data:1 Active, 2 Tested

AID:: 220174

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 24221314.

Inhibition of human PDE1 partially purified from THP-1 cells

Source:: ChEMBL

Protein Targets:: Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A; ...
Total:: 3

Assay data:6 Active, 2 Activity ≤ 1 µM, 16 Tested

AID:: 242213

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 15892115.

Inhibition of phosphodiesterase 1/5 (PDE1/5) from guinea pig tracheal smooth muscle cells (Not determined)

Source:: ChEMBL

Protein Targets:: Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A; ...
Total:: 4

Assay data:4 Tested

AID:: 158921

Summary PubMed Citation Related BioAssays by Target

Select item 15892016.

Inhibitory activity against phosphodiesterase 1/5 (PDE1/5) extracted from guinea pig trachea smooth muscle cells by using radioligands [3H]-cAMP or [3H]cGMP

Source:: ChEMBL

Protein Targets:: Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A; ...
Total:: 4

Assay data:17 Tested

AID:: 158920

Summary PubMed Citation Related BioAssays by Target

Select item 15891917.

Inhibition of phosphodiesterase 1/5 isozyme (PDE1/5) mixture isolated from the guinea pig trachea.

Source:: ChEMBL

Protein Targets:: Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A; ...
Total:: 4

Assay data:2 Active, 35 Tested

AID:: 158919

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 15891618.

Inhibition of recombinant Phosphodiesterase 1

Source:: ChEMBL

Protein Targets:: Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A; ...
Total:: 3

Assay data:1 Tested

AID:: 158916

Summary PubMed Citation Related BioAssays by Target

Select item 15891519.

Selectivity ratio for Phosphodiesterase 1 and Phosphodiesterase 5

Source:: ChEMBL

Protein Targets:: Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A; ...
Total:: 4

Assay data:2 Tested

AID:: 158915

Summary PubMed Citation Related BioAssays by Target

Select item 15891420.

Selective inhibition of PDE5 versus PDE1

Source:: ChEMBL

Protein Targets:: Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A; ...
Total:: 4

Assay data:7 Tested

AID:: 158914

Summary PubMed Citation Related BioAssays by Target

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Target

RNAi Target, Active (6)
BioAssays with gene sequences specified as RNAi targets and the activity is active

BioActivity

Active Compounds (79)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (14)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (62)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Summary (1)
BioAssays summarizing information from multiple assays for validated chemical probes or small molecule leads
Confirmatory (139)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
Primary Screening (9)
Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose
Chemical Screens (182)
BioAssays reporting BioActivity of chemical reagents
RNAi Screens (13)
BioAssays reporting BioActivity of RNAi reagents

Assay Project (1)
BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

Depositor Category

Literature Extraction (181)
BioAssays extracted from the literature
NIH MLP (1)
BioAssays deposited by the NIH Molecular Libraries Program
Other (13)
BioAssays deposited by other experimentalists

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BioAssay by Target (List) for Gene (Select 5153) (195)
PubChem BioAssay
GEO Profile Links for Gene (Select 5153) (1000)
GEO Profiles
CDK17 cyclin dependent kinase 17 [Homo sapiens]
CDK17 cyclin dependent kinase 17 [Homo sapiens]
Gene ID:5128

Gene
Gene Links for GEO Profiles (Select 119575579) (1)
Gene
NPW neuropeptide W [Homo sapiens]
NPW neuropeptide W [Homo sapiens]
Gene ID:283869

Gene

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