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Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced TNF-alpha response in human macrophages_Primary screen TNF readout
Assay data:2853 Active, 18113 Tested
SummaryRelated BioAssays by Same Project
Binding affinity to human recombinant PGAM1 by SYPRO orange dye fluorescence based thermal shift assay
Assay data:1 Active, 1 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Allosteric binding affinity to human recombinant PGAM1 assessed as increase in fluorescence intensity from compound-unbound form of PGAM1 using increasing concentrations of 3-PG by tryptophan fluorescence detection based 3-PG competitive binding assay
Binding affinity to human recombinant PGAM1 by tryptophan fluorescence detection based 3-PG competitive binding assay
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
Inhibition of recombinant human His-tagged PGAM1 expressed in Escherichia coli BL21 competent cells by kinase-glo assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of recombinant human PGAM1 using 3-PG as substrate by fluorescence based assay
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Binding affinity to PGAM1 (unknown origin) assessed as change in melting temperature by SYPRO Orange-dye based fluorescence thermal shift assay
Inhibition of recombinant PGAM1 (unknown origin) at 20 uM using 3-PG as substrate preincubated for 2 mins followed by substrate addition relative to control
Assay data:19 Tested
Inhibition of recombinant PGAM1 (unknown origin) using 3-PG as substrate preincubated for 2 mins followed by substrate addition
Assay data:19 Active, 2 Activity ≤ 1 µM, 38 Tested
Inhibition of PGAM1 (unknown origin)
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of PGAM1 in human MDA-MB-231 cells using 3-PGA as substrate after 2 hrs in by UV-vis spectrophotometric method
Inhibition of PGAM1 in human NCI-H1299 cells assessed as reduction in 2-PG levels at 20 uM by spectrophotometry
Inhibition of PGM1 (unknown origin) by enzymatic assay
A screen to identify synthetic lethal interactions with E-cadherin in an MCF10A isogenic cell line
Assay data:2442 Active, 18052 Tested
SummaryPubMed Citation
A screen to identify genes that regulate lymphatic endothelial cell migration - Primary Screen
Assay data:1034 Active, 18120 Tested
SummaryRelated BioAssays by Depositor
Identification of proteins required for the processing of the EWS-FLI1 nascent transcript
Assay data:59220 Tested
InfectX: Pathogen infection siRNA screens
Assay data:115372 Tested
A whole genome RNAi screen highlights components of the ER/Golgi as a prominent source of resistance to immunotoxin-mediated cytotoxicity
Assay data:555 Active, 64752 Tested
RNAi screen for vorinostat resistance genes - Secondary Deconvolution Screen
Assay data:732 Active, 1804 Tested
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