BioAssay by Target (List) for Gene (Select 5289) - PubChem BioAssay - NCBI

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Select item 19466741.

Inhibition of VPS34 (unknown origin)

Source:: ChEMBL

Protein Target:: Phosphatidylinositol 3-kinase catalytic subunit type 3

Assay data:28 Active, 1 Activity ≤ 1 nM, 33 Activity ≤ 1 µM, 35 Tested

AID:: 1946674

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19379072.

Inhibition of PIK3C3 (unknown origin) assessed as dissociation constant

Source:: ChEMBL

Protein Target:: Phosphatidylinositol 3-kinase catalytic subunit type 3

Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1937907

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19223913.

Binding affinity to Vps34 (unknown origin)

Source:: ChEMBL

Protein Target:: Phosphatidylinositol 3-kinase catalytic subunit type 3

Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested

AID:: 1922391

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19214034.

Induction of VPS34 degradation in HEK293 cells

Source:: ChEMBL

Protein Target:: Phosphatidylinositol 3-kinase catalytic subunit type 3

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1921403

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19214015.

Induction of VPS34 degradation in HEK293 cells assessed as maximum degradation at 300 nM after 48 hrs relative to control

Source:: ChEMBL

Protein Target:: Phosphatidylinositol 3-kinase catalytic subunit type 3

Assay data:1 Tested

AID:: 1921401

Summary PubMed Citation Related BioAssays by Target

Select item 19213996.

Induction of VPS34 degradation in HEK293 cells assessed as maximum degradation after 30 mins relative to control

Source:: ChEMBL

Protein Target:: Phosphatidylinositol 3-kinase catalytic subunit type 3

Assay data:1 Tested

AID:: 1921399

Summary PubMed Citation Related BioAssays by Target

Select item 19198337.

Vps34 Biochemical Assay from US Patent US11780858: "Pyridinamine-pyridone and pyrimidinamine-pyridone compounds"

Source:: BindingDB

Protein Targets:: Phosphatidylinositol 3-kinase catalytic subunit type 3; ...
Total:: 1

Assay data:20 Active, 20 Activity ≤ 1 µM, 20 Tested

AID:: 1919833

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19194408.

PI3K-Alpha kinase (PIK3CA) activity, wild-type and H1047R mutant and determining IC50 values for inhibitors from US Patent US11649227: "Allosteric chromenone inhibitors of phosphoinositide 3-kinase (PI3K) for the treatment of disease"

Source:: BindingDB

Protein Targets:: DNA-dependent protein kinase catalytic subunit; ...
Total:: 7

Assay data:92 Active, 74 Activity ≤ 1 µM, 98 Tested

AID:: 1919440

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19193939.

Vps34 Biochemical Assay from US Patent US11633403: "6-aryl-4-morpholin-1-ylpyridone compounds useful for the treatment of cancer and diabetes"

Source:: BindingDB

Protein Targets:: Phosphatidylinositol 3-kinase catalytic subunit type 3; ...
Total:: 1

Assay data:17 Active, 17 Activity ≤ 1 µM, 17 Tested

AID:: 1919393

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 191923410.

Vps34 Biochemical Assay from US Patent US11560374: "Morpholinylpyridone compounds"

Source:: BindingDB

Protein Targets:: Phosphatidylinositol 3-kinase catalytic subunit type 3; ...
Total:: 1

Assay data:17 Active, 17 Activity ≤ 1 µM, 17 Tested

AID:: 1919234

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 191901911.

Biochemical Assay from US Patent US11498919: "Azaindolylpyridone and diazaindolylpyridone compounds"

Source:: BindingDB

Protein Targets:: Phosphatidylinositol 3-kinase catalytic subunit type 3; ...
Total:: 1

Assay data:26 Active, 26 Activity ≤ 1 µM, 26 Tested

AID:: 1919019

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 191379212.

Selectivity interaction (SelectScreen panel (Invitrogen)) EUB0000685a PIK3C3

Source:: ChEMBL

Protein Target:: Phosphatidylinositol 3-kinase catalytic subunit type 3

Assay data:1 Tested

AID:: 1913792

Summary Related BioAssays by Target

Select item 191379113.

Selectivity interaction (Enzymatic assay) EUB0000685a PIK3C3

Source:: ChEMBL

Protein Target:: Phosphatidylinositol 3-kinase catalytic subunit type 3

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1913791

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 191308514.

Affinity Biochemical interaction (Radioactive liposome kinase assay) EUB0000631a PIK3C3

Source:: ChEMBL

Protein Target:: Phosphatidylinositol 3-kinase catalytic subunit type 3

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1913085

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 191267215.

Affinity Phenotypic Cellular interaction (Inhibition of PtdIns(3)P levels (at endosomes probed by suppression of endosomal localization of GFP?2 FYVEHrs; U2OS cells)) EUB0000631a PIK3C3

Source:: ChEMBL

Protein Target:: Phosphatidylinositol 3-kinase catalytic subunit type 3

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1912672

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 188211516.

Inhibition of human wild type N-terminal GST tagged VPS34 (1 to 887 end) expressed in baculovirus infected Sf21 insect cells using PI and Phosphatidylserine as substrate preincubated with compound for 20 mins followed by substrate addition measured after 90 mins in presence of ATP by ADP-Glo kinase based luminescence assay

Source:: ChEMBL

Protein Target:: Phosphatidylinositol 3-kinase catalytic subunit type 3

Assay data:24 Active, 23 Activity ≤ 1 µM, 24 Tested

AID:: 1882115

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 184901217.

Inhibition of VPS34 (unknown origin) at 10 uM relative to control

Source:: ChEMBL

Protein Target:: Phosphatidylinositol 3-kinase catalytic subunit type 3

Assay data:4 Tested

AID:: 1849012

Summary PubMed Citation Related BioAssays by Target

Select item 183543818.

VPS34 DiscoveRx kinase panel

Source:: ChEMBL

Protein Target:: Phosphatidylinositol 3-kinase catalytic subunit type 3

Assay data:1 Tested

AID:: 1835438

Summary Related BioAssays by Target

Select item 180706519.

Inhibition of PIK3C3 (unknown origin) assessed as reduction in substrate phosphorylation by FRET Adapta assay

Source:: ChEMBL

Protein Target:: Phosphatidylinositol 3-kinase catalytic subunit type 3

Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested

AID:: 1807065

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 180643920.

VPS34 ADP-Glo kinase assay from WIPO Patent WO2022093820: "SUBSTITUTED MORPHOLINE COMPOUNDS"

Source:: BindingDB

Protein Targets:: Phosphatidylinositol 3-kinase catalytic subunit type 3; ...
Total:: 1

Assay data:47 Active, 35 Activity ≤ 1 µM, 68 Tested

AID:: 1806439

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

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Target

Proteins (1)
BioAssays with protein sequences specified as targets
RNAi Target, Active (7)
BioAssays with gene sequences specified as RNAi targets and the activity is active

BioActivity

Active Compounds (85)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (4)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (65)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Summary (1)
BioAssays summarizing information from multiple assays for validated chemical probes or small molecule leads
Confirmatory (92)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
Primary Screening (40)
Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose
Chemical Screens (150)
BioAssays reporting BioActivity of chemical reagents
RNAi Screens (44)
BioAssays reporting BioActivity of RNAi reagents

Assay Project (1)
BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

Depositor Category

Literature Extraction (136)
BioAssays extracted from the literature
NIH MLP (1)
BioAssays deposited by the NIH Molecular Libraries Program
Other (57)
BioAssays deposited by other experimentalists

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BioAssay by Target (List) for Gene (Select 5289) (194)
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BioAssays, RNAi Target, Active for Gene (Select 5289) (2)
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Mammuthus primigenius mitochondrion, complete genome
Mammuthus primigenius mitochondrion, complete genome
gi|124056416|ref|NC_007596.2|

Nucleotide
Full text in PMC (nucleotide) for Gene (Select 642696) (78)
PMC
Influenza A effect on plasmacytoid dendritic cells
Influenza A effect on plasmacytoid dendritic cells
Accession: GDS6063

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