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Binding affinity to PKL (unknown origin)
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of PKL (unknown origin)
Inhibition of PKL in human PKM2 knockout HepG2 cells at 10 uM incubated for 5 mins by Microplate reader based analysis relative to control
Assay data:25 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of PKL (unknown origin) at 10 uM for 30 mins by Kinase-Glo Max reagent based luminescence assay
Assay data:47 Tested
Inhibition of PKL (unknown origin) for 30 mins by Kinase-Glo Max reagent based luminescence assay
Assay data:25 Active, 10 Activity ≤ 1 µM, 40 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Allosteric activation of wild type N-terminal His6-fused pyruvate kinase-R (unknown origin) expressed in Escherichia coli BL21 incubated for 30 mins by spectrophotometric method
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
Inhibition of recombinant human N-terminal His-tagged PKL expressed in Escherichia coli preincubated for 15 mins followed by PEP/NADH addition measured at 30 secs interval for 3 to 6 mins by fluorescent PK-LDH assay
Assay data:2 Active, 3 Tested
Inhibition of recombinant human N-terminal His-tagged PKL expressed in Escherichia coli preincubated for 25 mins in presence of PEP/FBP followed by ADP/NADH addition measured after 25 mins by PK-LDH assay
Assay data:1 Active, 2 Tested
Activation of wild type PKR (unknown origin) by cell based assay
Assay data:204 Active, 198 Activity ≤ 1 µM, 343 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Activation of wild type PKR (unknown origin) incubated for 60 mins in presence of ADP, PEP and NADH by Spectraax microplate reader based assay
Assay data:317 Active, 277 Activity ≤ 1 µM, 343 Tested
Activation of PKR R532W mutant (unknown origin) incubated for 60 mins in presence of ADP, PEP and NADH by Spectraax microplate reader based assay
Assay data:311 Active, 276 Activity ≤ 1 µM, 343 Tested
Activation of PKR R510Q mutant (unknown origin) incubated for 60 mins in presence of ADP, PEP and NADH by Spectraax microplate reader based assay
Assay data:278 Active, 222 Activity ≤ 1 µM, 343 Tested
Activation of PKR R479H mutant (unknown origin) using PEP as substrate preincubated with substrate for 60 mins followed by ADP addition by microplate reader analysis
Assay data:1 Active, 2 Activity ≤ 1 µM, 2 Tested
Activation of PKR G364D mutant (unknown origin) using PEP as substrate preincubated with substrate for 60 mins followed by ADP addition by microplate reader analysis
Activation of PKR T384W mutant (unknown origin) using PEP as substrate preincubated with substrate for 60 mins followed by ADP addition by microplate reader analysis
Assay data:6 Active, 7 Activity ≤ 1 µM, 7 Tested
Activation of PKR R532W mutant (unknown origin) using PEP as substrate preincubated with substrate for 60 mins followed by ADP addition by microplate reader analysis
Assay data:7 Active, 9 Activity ≤ 1 µM, 9 Tested
Activation of PKR R510Q mutant (unknown origin) using PEP as substrate preincubated with substrate for 60 mins followed by ADP addition by microplate reader analysis
Assay data:4 Active, 11 Activity ≤ 1 µM, 11 Tested
Activation of wild type PKR (unknown origin) using PEP as substrate preincubated with substrate for 60 mins followed by ADP addition by microplate reader analysis
Activation of wild type PKR (unknown origin) using PEP as substrate at 1 uM preincubated with substrate for 60 mins followed by ADP addition by microplate reader analysis relative to control
Assay data:63 Tested
SummaryRelated BioAssays by Target
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