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Inhibition of uPAR/uPA (unknown origin) interaction assessed as dissociation constant by fluorescence polarization (FP) assay
Assay data:7 Active, 1 Activity ≤ 1 µM, 8 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of uPAR/uPA (unknown origin) interaction by ELISA
Assay data:5 Active, 8 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Fluorescence Polarization Assay from Article 10.1021/acs.biochem.6b01039: "Small Molecules Engage Hot Spots through Cooperative Binding To Inhibit a Tight Protein-Protein Interaction."
Assay data:33 Active, 6 Activity ≤ 1 µM, 42 Tested
Inhibition of AE147-FAM peptide binding to recombinant soluble form urokinase-type plasminogen activator receptor (unknown origin) expressed in S2 cells preincubated for 15 min followed by AE147-FAM peptide addition by fluorescence polarization assay relative to control
Assay data:17 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of biotin-labeled 8B12 binding to recombinant soluble form urokinase-type plasminogen activator receptor (unknown origin) expressed in S2 cells by biolayer interferometry
Assay data:2 Tested
Binding affinity to NT-495-labelled recombinant soluble form urokinase-type plasminogen activator receptor (unknown origin) expressed in S2 cells measured after 20 mins by microscale thermophoresis analysis
Assay data:3 Tested
Inhibition of AE147-FAM peptide binding to recombinant soluble form urokinase-type plasminogen activator receptor (unknown origin) expressed in S2 cells preincubated for 15 min followed by AE147-FAM peptide addition by fluorescence polarization assay
Assay data:8 Active, 17 Tested
Binding affinity to recombinant soluble form urokinase-type plasminogen activator receptor (unknown origin) expressed in S2 cells assessed as inhibition of uPAR-uPA ATF protein-protein interaction measured after 30 mins by ELISA
Assay data:5 Active, 2 Activity ≤ 1 µM, 17 Tested
Binding affinity to recombinant soluble form urokinase-type plasminogen activator receptor (unknown origin) expressed in S2 cells assessed as inhibition of uPAR-biotin-labeled uPA ATF protein-protein interaction by biolayer interferometry
Assay data:2 Active, 3 Tested
Binding affinity to recombinant soluble form urokinase-type plasminogen activator receptor (unknown origin) expressed in S2 cells assessed as inhibition of uPAR-uPA ATF protein-protein interaction up to 10 uM measured after 30 mins in presence of 0.01 to 0.1% Triton X-100 by ELISA
Assay data:1 Active, 1 Tested
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
Binding affinity to uPAR (unknown origin) assessed as reduction in uPA-uPAR protein interaction
SummaryCompounds, ActiveRelated BioAssays by Target
Binding affinity to uPAR (unknown origin)
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced TNF-alpha response in human macrophages_Primary screen TNF readout
Assay data:2853 Active, 18113 Tested
SummaryRelated BioAssays by Same Project
A screen to identify synthetic lethal interactions with E-cadherin in an MCF10A isogenic cell line
Assay data:2442 Active, 18052 Tested
SummaryPubMed Citation
A screen to identify genes that regulate lymphatic endothelial cell migration - Primary Screen
Assay data:1034 Active, 18120 Tested
SummaryRelated BioAssays by Depositor
Identification of proteins required for the processing of the EWS-FLI1 nascent transcript
Assay data:59220 Tested
InfectX: Pathogen infection siRNA screens
Assay data:115372 Tested
A whole genome RNAi screen highlights components of the ER/Golgi as a prominent source of resistance to immunotoxin-mediated cytotoxicity
Assay data:555 Active, 64752 Tested
RNAi screen for vorinostat resistance genes - Primary Screen
Assay data:450 Active, 18118 Tested
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