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Inhibitory activity against Somatostatin receptor in rat cortex membrane using 125 I-Tyrs-octreotide as radioligand
Assay data:1 Tested
SummaryRelated BioAssays by Target
Compound was tested for in vitro SRIF inhibition of GH release in rats
Assay data:21 Active, 18 Activity ≤ 1 µM, 26 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
SRIF inhibition of GH release in rats
Assay data:17 Tested
SummaryPubMed CitationRelated BioAssays by Target
Antagonism of in vitro SRIF inhibition of GH release from rat pituitary cells in culture
Assay data:8 Active, 1 Activity ≤ 1 nM, 8 Activity ≤ 1 µM, 8 Tested
Antagonism of in vitro SRIF inhibition of GH release from rat pituitary cells in culture; not determined
Assay data:10 Tested
Antagonism of in vitro SRIF inhibition of GH release from rat pituitary cells in culture; not determined; not determined
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
Ability to inhibit binding of [3I]-CGP 23996 to somatostatin receptor on membranes from cerebral cortex
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Ability to inhibit binding of [3I]-CGP 23996 to somatostatin receptor on membranes from pituitary
Antagonism of in vitro SRIF inhibition of GH release in rat in vitro pituitary cell assay
Assay data:42 Active, 39 Activity ≤ 1 µM, 44 Tested
Binding affinity in competition with [125I]- CGP-23996 in somatostatin receptor binding to rat brain membrane
Assay data:12 Active, 1 Activity ≤ 1 µM, 20 Tested
Binding affinity of compound in competition with [125I]- CGP-23996 in somatostatin receptor binding to rat brain membrane; Not determined
Compound was tested for its inhibitory effect against somatostatin receptor in rat cortex membrane using [125I]Tyr3-octreotide as the radioligand
Assay data:3 Active, 2 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Compound was tested for its potency to displace 3-[125I]- - Tyr11-SRIF-14 from somatostatin receptor on membranes of rat cerebral cortex
Assay data:2 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 7 Tested
Radioligand binding studies on rat cortex membranes using 125 I-Tyrs-octreotide as ligand was determined
SummaryCompounds, ActiveRelated BioAssays by Target
Agonist activity at rat SST2 receptor
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
The displacement of [64Cu]-TETA-OC by the compound on rat CA20948 pancreatic tumor cell membranes
Assay data:4 Active, 4 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 4 Tested
In vitro binding affinity of [111In]DTPA-[Y3]-octreotate to somatostatin receptor in the rat pancreatic tumor cell line, CA20498
Assay data:14 Active, 2 Activity ≤ 1 nM, 15 Activity ≤ 1 µM, 15 Tested
In vivo tumor accumulation was determined in nude mice bearing rat pancreatic AR42J tumor cell expressed with somatostatin receptor type 2;60 min p.i.; (n=3-5)
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