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Metabolic stability in human liver microsomes S9 fraction assessed as UGT-mediated metabolism by measuring parent compound remaining measured after 15 mins in presence of NADPH
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by Target
Drug metabolism in human liver microsome S9 fraction assessed as UGT-mediated metabolism by measuring compound remaining at 5 uM pretreated with UDPGA and measured after 60 mins by UPLC-MS/MS analysis
Assay data:3 Tested
Inhibition of recombinant human C-terminal His-tagged UGT1A10 after 15 to 60 mins by Michaelis-Menten equation analysis in presence of UDPGA
Assay data:1 Tested
Drug metabolism assessed as human recombinant UGT1A10-mediated irilone-O-4'-monoglucuronide formation incubated for 5 mins prior to UDPGA addition measured after 90 mins by HPLC-DAD analysis
Activity of human recombinant UGT1A10 expressed in baculovirus-infected Sf9 cells assessed as enzyme-mediated glucuronidation per mg protein after 60 mins by Michaelis-Menten equation in presence of 3 mM UDP-GlcUA
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