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Metabolic stability in human liver microsomes S9 fraction assessed as UGT-mediated metabolism by measuring parent compound remaining measured after 60 mins in presence of NADPH
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by Target
Metabolic stability in human liver microsomes S9 fraction assessed as UGT-mediated metabolism by measuring parent compound remaining measured after 30 mins in presence of NADPH
Metabolic stability in human liver microsomes S9 fraction assessed as UGT-mediated metabolism by measuring parent compound remaining measured after 15 mins in presence of NADPH
Metabolic stability assessed as human UGT-mediated metabolism by measuring half life by phase II UGT conjugation assay
Assay data:1 Tested
Metabolic stability in human assessed as UGT-mediated metabolism by measuring half life
Metabolic stability assessed as human UGT-mediated metabolism by measuring half life
Metabolic stability of the compound in human liver microsomes S9 fraction assessed as UGT-mediated metabolism by measuring parent compound remaining at 5 uM measured after 60 mins in presence of UDPGA by UPLC-MS analysis
Metabolic stability of the compound in human liver microsomes S9 fraction assessed as UGT-mediated metabolism by measuring parent compound remaining at 5 uM measured after 30 mins in presence of UDPGA by UPLC-MS analysis
Metabolic stability of the compound in human liver microsomes S9 fraction assessed as UGT-mediated metabolism by measuring parent compound remaining at 5 uM measured after 15 mins in presence of UDPGA by UPLC-MS analysis
Metabolic stability in human liver microsomes assessed as UGT-mediated N-glucuronidation by measuring intrinsic clearance at 3 uM measured up to 45 mins by LC-MS/MS analysis
Assay data:3 Tested
Metabolic stability in human liver microsomes assessed as UGT-mediated N-glucuronidation by measuring half life at 3 uM measured up to 45 mins by LC-MS/MS analysis
Metabolic stability in human hepatocytes assessed as UGT-mediated compound glucuronidation by measuring half life
Drug metabolism in human hepatocytes assessed as UGT-mediated glucuronidation at 10 uM measured after 4 hrs in presence of hydroxylamine by LC-MS/MS analysis
Drug metabolism in human hepatocytes assessed as UGT-mediated glucuronidation at 10 uM measured after 4 hrs by LC-MS/MS analysis
Substrate activity at UDP-glycosyltransferase (unknown origin) assessed as enzyme-mediated metabolite formation in presence of UP-glucose by HPLC-LC/MS analysis
Drug metabolism in human liver S9 fraction assessed as UGT-mediated metabolism by measuring parent compound remaining at 5 uM measured after 60 mins in presence of UDPGA by UPLC analysis
Drug metabolism in human liver S9 fraction assessed as UGT-mediated metabolism by measuring parent compound remaining at 5 uM measured after 30 mins in presence of UDPGA by UPLC analysis
Drug metabolism in human liver S9 fraction assessed as UGT-mediated metabolism by measuring parent compound remaining at 5 uM measured after 15 mins in presence of UDPGA by UPLC analysis
Drug metabolism in human liver S9 fraction assessed as UGT-mediated metabolism by measuring parent compound remaining at 5 uM measured immediately in presence of UDPGA by UPLC analysis
Drug metabolism in human liver S9 fraction assessed as UGT-mediated metabolism by measuring compound remaining at 5 uM incubated for 60 mins in presence of UDPGA by UPLC-MS analysis
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