Warning: The NCBI web site requires JavaScript to function. more...
An official website of the United States government
The .gov means it's official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.
The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.
Inhibition of CypA (unknown origin)
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Binding affinity to CypA (unknown origin)
Assay data:4 Active, 1 Activity ≤ 1 µM, 5 Tested
Surface Plasmon Resonance (SPR) Assay from US Patent US11802108: "Compounds for the modulation of cyclophilins function"
Assay data:6 Active, 6 Activity ≤ 1 µM, 6 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Isothermal Titration Calorimetry (ITC) from US Patent US11802108: "Compounds for the modulation of cyclophilins function"
Assay data:8 Active, 4 Activity ≤ 1 µM, 21 Tested
Inhibition of CypA (unknown origin) upto 20 uM
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by Target
Binding affinity to CypA (unknown origin) assessed as inhibition constant by isomer specific proteolysis assay
Assay data:3 Active, 1 Activity ≤ 1 µM, 5 Tested
Binding affinity to His6-tagged CypA (unknown origin) expressed in Escherichia coli BL21 (DE3) incubation at 1 hr by multimode plate reader
Assay data:6 Active, 11 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition Assay from US Patent US9090657: "Compound and methods for its production"
Assay data:4 Active, 2 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 4 Tested
Surface Plasmon Resonance Assay from Article 10.1021/cc0501561: "Strategy for discovering chemical inhibitors of human cyclophilin a: focused library design, virtual screening, chemical synthesis and bioassay."
Assay data:10 Active, 5 Activity ≤ 1 µM, 16 Tested
PPIase Assay from Article 10.1021/bi9007287: "Isoform-specific inhibition of cyclophilins."
Assay data:4 Active, 2 Activity ≤ 1 µM, 9 Tested
PPIase Assay from Article 10.1002/cbic.201000413: "Design and synthesis of conformationally constrained cyclophilin inhibitors showing a cyclosporin-A phenotype in C. elegans."
Assay data:1 Active, 5 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Fluorescence Assay from Article 10.1002/cbic.201000413: "Design and synthesis of conformationally constrained cyclophilin inhibitors showing a cyclosporin-A phenotype in C. elegans."
Assay data:4 Tested
SummaryPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
ESI-MS Assay from Article 10.1002/cbic.201000413: "Design and synthesis of conformationally constrained cyclophilin inhibitors showing a cyclosporin-A phenotype in C. elegans."
Assay data:6 Tested
Surface Plasmon Resonance (SPR) Assay from US Patent US9566312: "Cyclic peptides and use as medicines"
Assay data:105 Active, 77 Activity ≤ 1 nM, 105 Activity ≤ 1 µM, 105 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Protease-Free PPIase Assay from US Patent US10077289: "Cyclosporins modified on the MeBmt sidechain by heterocyclic rings"
Assay data:38 Active, 1 Activity ≤ 1 nM, 38 Activity ≤ 1 µM, 38 Tested
Binding affinity to Cyclophilin A (unknown origin) by surface plasmon resonance analysis
Assay data:1 Active, 1 Tested
Inhibition of PPIA (unknown origin) pre-incubated for 20 mins followed by fluorescence substrate addition and measured after 120 mins by DiFMUP assay
Assay data:1 Tested
Inhibition of C-terminal His6-tagged CypA (unknown origin) expressed in Escherichia coli C41(DE3) using Suc-Ala-Ala-Cis-Pro-Phe-pNA as substrate by spectrophotometric analysis
Assay data:1 Active, 1 Activity ≤ 1 µM, 4 Tested
Inhibition of recombinant N-terminal His6-tagged Cyclophilin A (unknown origin) expressed in Escherichia coli at 1 to 50 uM using Suc-AEPF-pNA as substrate preincubated for 10 min followed by substrate addition measured for 180 secs
Filters: Manage Filters
Your browsing activity is empty.
Activity recording is turned off.
Turn recording back on