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Inhibition of YFP tagged ANO1 (unknown origin) expressed in FRT cells at 30 uM incubated for 24 hrs by whole cell patch clamp electrophysiology relative to control
Assay data:4 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of YFP tagged ANO1 (unknown origin) expressed in FRT cells incubated for 24 hrs by fluorescence plate reader assay
Assay data:23 Active, 8 Activity ≤ 1 µM, 36 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Automated Whole-Cell Patch Clamp Assay from US Patent US11364246: "Compounds"
Assay data:229 Active, 193 Activity ≤ 1 µM, 229 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition of ANO1 Over ANO2 from US Patent US11274074: "Pharmaceutical composition for ANO1 antagonist with anticancer activity"
Assay data:3 Active, 3 Activity ≤ 1 µM, 33 Tested
Automated Whole-Cell Patch Clamp Assay to Detect TMEM16A Activity in Recombinant Cells from US Patent US20200361871: "COMPOUNDS"
Inhibition of human ANO1 expressed in FRT cells assessed as inhibition of ATP-induced channel current treated 20 mins prior to ATP challenge and measured by pacth-clamp technique
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
Inhibition of ANO1 channel (unknown origin)
Inhibition of ANO1 in human U251 cells assessed as inhibition of channel current at 10 uM by patch clamp electrophysiology assay
Assay data:2 Tested
Induction of ANO1 degradation in human U251 cells at 10 uM incubated for 24 hrs by western blot analysis
Assay data:2 Active, 2 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Induction of ANO1 degradation in human U251 cells at 10 uM preincubated with compound for 6 hrs followed by treatment with proteasome inhibitor, MG132 for 18 hrs by western blot analysis
Inhibition of human ANO1 channel expressed in HEK293 cells incubated for 10 mins by FLIPR assay
Assay data:10 Active, 1 Activity ≤ 1 µM, 10 Tested
Inhibition of human ANO1 channel expressed in HEK293 cells at 10 uM incubated for 10 mins by FLIPR assay relative to control
Assay data:36 Tested
Inhibition of ANO1 (unknown origin) expressed in FRT cells assessed as reduction in ATP-induced chloride current after 20 mins by electrophysiological assay
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of YFP-fused ANO1 (unknown origin) expressed in FRT cells after 20 mins by fluorescence quenching method
Assay data:5 Active, 5 Activity ≤ 1 µM, 27 Tested
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
Inhibition of human TMEM16A expressed in FRT cells assessed as reduction in carbachol activated chloride conductance at 1 uM preincubated for 5 mins followed by carbachol addition by short-circuit current assay
Assay data:1 Active, 1 Tested
Inhibition of human TMEM16A expressed in FRT cells assessed as alteration of ATP stimulated cytoplasmic calcium elevation at 1 uM preincubated for 3 mins followed by ATP addition by Fluo-4 fluorescence assay
Inhibition of human TMEM16A expressed in FRT cells assessed as reduction in ionomycin activated chloride conductance at 1 uM preincubated for 5 mins followed by ionomycin addition by short-circuit current assay
Reversible inhibition of human TMEM16A expressed in FRT cells assessed as recovery of Ca2+ activated chloride current at 250 nM preincubated with cells followed by compound washout at -60 mV holding potential by inside-out patch-clamp method
Assay data:1 Tested
Inhibition of human TMEM16A expressed in FRT cells assessed as reduction in Ca2+ activated chloride current at 250 nM at -60 mV holding potential by inside-out patch-clamp method
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