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Nicotinic Acetylcholine Eurofins Panlabs panel
Assay data:1 Tested
SummaryRelated BioAssays by Target
Inhibition of human alpha9alpha10 nAChR expressed in xenopus oocytes assessed as inhibition of Ach- induced response at -70 mV holding potential and measured for 1 to 5 days in presence of Ach stimulation by voltage-clamp based electrophysiological method
Assay data:12 Active, 7 Activity ≤ 1 nM, 15 Activity ≤ 1 µM, 16 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Antagonist activity at human alpha9alpha10 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of ACh-induced current amplitude at -80 mV holding potential at 100 nM by two-electrode voltage clamp method
Assay data:5 Active, 26 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Antagonist activity at human alpha9alpha10 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of ACh-induced current amplitude at -80 mV holding potential by two-electrode voltage clamp method
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
Antagonist activity at human alpha9alpha10 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of ACh-induced current amplitude at -80 mV holding potential at 10 uM by two-electrode voltage clamp method
Assay data:2 Active, 5 Tested
Antagonist activity at human alpha9alpha10 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of ACh-induced current amplitude at -80 mV holding potential at 1 uM by two-electrode voltage clamp method
Assay data:5 Tested
SummaryPubMed CitationRelated BioAssays by Target
Antagonist activity at human alpha9alpha10 nAChR expressed in Xenopus laevis oocytes assessed as rebound current at 100 uM treated for 1 sec at holding potential of -70 mVby two electrode voltage-clamp assay
Assay data:1 Active, 1 Tested
Partial agonist activity at human alpha9alpha10 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of acetylcholine-induced current response by measuring efficacy at 100 uM treated for 1 sec at holding potential of -70 mV by two electrode voltage-clamp assay relative to control
Assay data:4 Tested
Antagonist activity at human alpha9alpha10 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of acetylcholine-induced current response at 100 uM treated for 1 sec in presence of acetylcholine at holding potential of -70 mV by two electrode voltage-clamp assay relative to control
Assay data:2 Active, 13 Tested
Antagonist activity at human alpha9alpha10 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of acetylcholine-induced current response treated for 1 sec in presence of acetylcholine at holding potential of -70 mV by two electrode voltage-clamp assay
Assay data:13 Active, 13 Activity ≤ 1 µM, 13 Tested
Inhibition of human nAChR alpha9alpha10 expressed in Xenopus laevis oocytes holding potential of -70 mV by voltage-clamp based electrophysiological method
Assay data:1 Active, 1 Activity ≤ 1 µM, 2 Tested
Inhibition of human alpha9alpha10 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of acetylcholine-induced current response by two-electrode voltage-clamp method
Assay data:7 Active, 2 Activity ≤ 1 nM, 8 Activity ≤ 1 µM, 8 Tested
NACH/H Eurofins SafetyScreen44 (BI)
Antagonist activity at nAChR in human PC-3 cells assessed as reduction in cytoplasmic free calcium level at 5 uM measured upto 6 hrs by Fura2-AM dye based fluorescence assay
Antagonist activity at nAChR in human HT-29 cells assessed as reduction in cytoplasmic free calcium level at 5 uM measured upto 6 hrs by Fura2-AM dye based fluorescence assay
Antagonist activity at nAChR in human MDA-MB-231 cells assessed as reduction cytoplasmic free calcium level at 5 uM measured upto 6 hrs by Fura2-AM dye based fluorescence assay
Antagonist activity at human alpha9/alpha10 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced response at 30 uM incubated for 5 mins by two electrode voltage-clamp assay
Antagonist activity at human alpha9alpha10 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced response incubated for 5 mins by two electrode voltage-clamp assay
Inhibition of human alpha9alpha10 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of acetylcholine-induced current response at 10 uM by two-electrode voltage-clamp method relative to control
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