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Binding affinity to recombinant human PKAC-alpha in human HeLa cells assessed as increase in intensity of fluorescent labeled bands at 5 uM incubated for 2 hrs in presence of forskolin by Western blot analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of recombinant human His-tagged PRKACA (1 to 351 residues) expressed in Escherichia coli expression system at 500 nM using Ser/Thr 01 as substrate incubated for 1 hr in presence of ATP at its Km concentration by Z'-LYTE assay relative to control
Assay data:6 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of recombinant human His-tagged PRKACA expressed in Escherichia coli at 10 uM in presence of ATP relative to control
Assay data:1 Tested
Inhibition of PKAC-alpha (unknown origin) assessed as remaining activity at 10 uM by high-throughput assay relative to control
Inhibition of human PKAC-alpha assessed as enzyme activity at 1 uM relative to control
Inhibition of human PKAalpha at 1 uM
Inhibition of PKAalpha (unknown origin) using serine/threonine 01 peptide as substrate after 1 hr by FRET based Z'-LYTE assay
Assay data:2 Active, 2 Activity ≤ 1 µM, 7 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of PRKACA (unknown origin)
Inhibition of PRKACA (unknown origin) at 1 uM by single point assay
Assay data:2 Tested
Inhibition of PRKACA at 10 uM by FRET assay
Inhibition of PKAalpha assessed as decrease in NADH absorbance at 340 nm in the presence of
Assay data:14 Active, 6 Activity ≤ 1 µM, 27 Tested
Inhibition of PKAalpha by scintillation proximity assay
Inhibition of protein kinase A (Not determined)
Assay data:4 Tested
SummaryRelated BioAssays by Target
Inhibition of Protein kinase A was (Not tested)
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