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Inhibition of RIOK2 (unknown origin) assessed as residual activity at 1 uM by Kinomescan assay relative to staurosporine
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of RIOK2 in human HT-29 cells assessed as reduction in mTOR phosphorylation >0.60 uM incubated for 4 hrs by Western blot analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of RIOK2 in human MKN-1 cells assessed as reduction in mTOR phosphorylation >0.60 uM incubated for 4 hrs by Western blot analysis
Binding affinity to RIOK2 in human MKN-1 cells assessed as negative shift in melting temperature at 5 uM incubated for 3 hrs followed by heat treatment at 52 to 62 degC for 3 mins by CETSA
Inhibition of N-terminal hexahistidine-SUMO-tagged human full length RIOK2 (residues 1 to 321) expressed in Escherichia coli BL21 (DE3) incubated for 30 mins in presence of ATP by ADP-Glo assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Binding affinity to wild-type human partial length RIOK2 (M1 to D313 residues) expressed in mammalian expression system assessed as residual activity at 1 uM by KINOMEscan assay relative to control
Binding affinity to wild-type human partial length RIOK2 (M1 to D313 residues) expressed in mammalian expression system assessed as dissociation constant by KINOMEscan assay
Assay data:17 Active, 22 Activity ≤ 1 µM, 22 Tested
Displacement of fluorescent tracer K5 from N-terminal full-length NanoLuc-fused RIOK2 (unknown origin) expressed in HEK293 cells using NanoGlo substrate incubated for 2 hrs by NanoBRET assay
Assay data:1 Active, 2 Tested
Binding affinity to RIOK2 (unknown origin) assessed as dissociation constant
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
RIOK2 DiscoveRx kinase panel
SummaryRelated BioAssays by Target
KinomeScan assay: inhibition of RIOK2
Assay data:108 Tested
RIOK2(RIO2LGF1) Takeda global kinase panel
Assay data:1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition of wild-type human partial length RIOK2 (M1 to D313 residues) expressed in mammalian expression system assessed as residual binding level at 1 uM by Kinomescan method relative to control
Inhibition of RIOK2 in HUVEC at 0.05 to 0.25 uM
Inhibition of RIOK2 in human VCaP cells after 48 hrs by Western blotting analysis
Inhibition of human RIOK2 by DiscoverX assay
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition of human RIOK2 at 2000 nM by KINOMEscan assay
Inhibition of human RIOK2 assessed as percent of control at 2000 nM by KINOMEscan assay relative to control
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