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Inhibition of PKC (unknown origin) using acetylated myelin basic protein (4 to 14 residues) as substrate incubated for [gamma-32P]-ATP incubated for 5 mins by scintillation counter analysis
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Activation of PKC in human THP-1 cells assessed as increase in ERK phosphorylation at 100 nM incubated for 15 mins by immunoblotting analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Activation of PKC in human THP-1 cells assessed as increase in ERK phosphorylation at 0.1 to 10 uM incubated for 15 mins by immunoblotting analysis
Assay data:3 Tested
Activation of PKC in human THP-1 cells assessed as increase in ERK phosphorylation at 10 uM pretreated with PMA for 24 hrs followed by compound addition and measured after 15 mins by immunoblotting analysis
Activation of PKC in human THP-1 cells assessed as increase in ERK phosphorylation incubated for 15 mins by immunoblotting analysis
Assay data:2 Tested
Inhibition of PKC (unknown origin)
Inhibition of Protein kinase C (unknown origin)
Assay data:3 Active, 1 Activity ≤ 1 µM, 6 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of human PKC
Affinity Biochemical interaction (Filter-binding assays) EUB0000154b PRKCG
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Affinity Phenotypic Cellular interaction (Antiproliferation against diverse cancer cell lines (HCT116; PC3-prostate cacinoma cell and U87MG glioblastoma cells)) EUB0000154b PRKCG
Inhibition of PKC gamma (unknown origin) at 50 nM by Z'LYTE screening method relative to control
Assay data:12 Tested
Displacement of 3H-PDBu from recombinant human PKCgamma incubated for 25 mins by scintillation counter analysis
Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested
PKCgamma(h) Kinase panel
SummaryRelated BioAssays by Target
Inhibition of PKCgamma (unknown origin)at 1 uM
Inhibition of human recombinant PKCgamma assessed as reduction in substrate phosphorylation at 50 to 500 nM using ATP and Ulight-CKKSRGDYMTMQIG (IRS-1) incubated for 60 min by LANCE detection method
PKA/PKC Kinase Assay from Article 10.1016/j.bmcl.2006.03.041: "Isoquinoline-pyridine-based protein kinase B/Akt antagonists: SAR and in vivo antitumor activity."
Assay data:4 Active, 1 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 4 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
PKA/PKC Kinase Assay from Article 10.1016/j.bmcl.2005.12.065: "Synthesis and structure-activity relationship of 3,4'-bispyridinylethylenes: discovery of a potent 3-isoquinolinylpyridine inhibitor of protein kinase B (PKB/Akt) for the treatment of cancer."
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
Kinase Inhibition Assay from Article 10.1016/S0960-894X(97)00445-9: "DISCOVERY AND STRUCTURE-ACTIVITY STUDIES OF A NOVEL SERIES OF PYRIDO[2,3-d]PYRIMIDINE TYROSINE KINASE INHIBITORS"
Assay data:25 Active, 15 Activity ≤ 1 µM, 28 Tested
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