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In Vitro Kinase Activity Assay from US Patent US11691950: "Isoquinoline-steroid conjugates and uses thereof"
Assay data:21 Active, 18 Activity ≤ 1 µM, 21 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Selectivity interaction (KinomeScan (DiscoverX, competition-binding assay)) EUB0000154b PRKCH
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of PKCeta (unknown origin) at 1 uM in presence of ATP at Km concentration by mobility shift assay relative to control
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of PKCeta (unknown origin) by Z'LYTE screening method relative to control
Inhibition of PKCeta (unknown origin) at 50 nM by Z'LYTE screening method relative to control
Assay data:12 Tested
Inhibition of PKCeta (unknown origin) by IMAP kinase assay
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of recombinant human full length PKCeta (2 to end residues) assessed as residual activity at 1 uM using ERMRPRKRQGSVRRRV as substrate incubated for 40 mins in presence of [gamma-33P]-ATP by scintillation counting method relative to control
Inhibition of PKC (unknown origin)
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
PRKCH DiscoveRx kinase panel
SummaryRelated BioAssays by Target
PKCeta (h) Kinase panel
Inhibition of PKCeta (unknown origin)at 1 uM
Protein Kinase Assays from Article 10.1021/jm901108b: "Discovery of 3-(1H-indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione (AEB071), a potent and selective inhibitor of protein kinase C isotypes."
Assay data:19 Active, 2 Activity ≤ 1 nM, 14 Activity ≤ 1 µM, 33 Tested
Kinase Inhibition Assay from Article 10.1016/S0960-894X(97)00445-9: "DISCOVERY AND STRUCTURE-ACTIVITY STUDIES OF A NOVEL SERIES OF PYRIDO[2,3-d]PYRIMIDINE TYROSINE KINASE INHIBITORS"
Assay data:25 Active, 15 Activity ≤ 1 µM, 28 Tested
PKC assay from Article 10.1016/0960-894X(95)00361-V: "Increasing the cellular PKC inhibitory activity of balanol: a study of ester analogs."
Assay data:16 Active, 1 Activity ≤ 1 nM, 16 Activity ≤ 1 µM, 16 Tested
PKC assay from Article 10.1021/jm960581w: "Synthesis and protein kinase C inhibitory activities of acyclic balanol analogs that are highly selective for protein kinase C over protein kinase A."
Assay data:26 Active, 1 Activity ≤ 1 nM, 23 Activity ≤ 1 µM, 26 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
PKC assay from Article 10.1016/0960-894X(95)00382-4: "SYNTHESIS AND BIOLOGICAL EVALUATION OF CONFORMATIONALLY CONSTRAINED BICYCLIC AND TRICYCLIC BALANOL ANALOGUES AS INHIBITORS OF PROTEIN KINASE C."
Assay data:13 Active, 1 Activity ≤ 1 nM, 10 Activity ≤ 1 µM, 13 Tested
PKC assay from Article 10.1016/0960-894X(95)00365-Z: "Ring Size effect in the PKC inhibitory activities of perhydroazepine analogs of balanol."
Assay data:5 Active, 1 Activity ≤ 1 nM, 5 Activity ≤ 1 µM, 5 Tested
KinomeScan assay: inhibition of PRKCH
Assay data:1 Active, 108 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
PKCeta(PRKHLGRA) Takeda global kinase panel
Assay data:1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, activity ≤ 1 µMRelated BioAssays by Target
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