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Thermal Shift Assay. Domain: start/stop: S32-N302
Assay data:1 Tested
SummaryRelated BioAssays by Target
Inhibition of TOPK (unknown origin) autophosphorylation measured after 3 hrs by multi-mode microplate reader
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
TOPK SGC Tm panel (DSF)
Inhibition of PBK (unknown origin) at 1 uM
SummaryPubMed CitationRelated BioAssays by Target
Kinase Assay from US Patent US8962648: "Tricyclic compounds and PBK inhibitors containing the same"
Assay data:223 Active, 20 Activity ≤ 1 nM, 223 Activity ≤ 1 µM, 223 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
PBK ProQinase selectivity panel
PBK DUNDEE kinase screen (BI)
Inhibition of TOPK (unknown origin) assessed as residual activity at 500 nM
Inhibition of PBK (unknown origin) assessed as residual activity measured at 1 uM
Assay data:3 Tested
Inhibition of human PBK at 1 uM using substrate peptide by off-chip mobility shift assay
Inhibition of PBK (unknown origin) assessed as residual activity at 1 uM by Kinomescan method relative to control
Inhibition of human PBK assessed as residual activity using MBP as substrate at 1 uM by [gamma-33P]-ATP assay relative to control
Inhibition of human PBK using MBP as substrate by [gamma-33P]-ATP assay
Inhibition of human PBK using MBP as substrate assessed as residual activity at 1 uM by [gamma-33P]-ATP assay relative to control
Assay data:2 Tested
Inhibition of PBK (unknown origin) at 1 uM relative to control
Inhibition of TOPK in human A549 cells assessed as reduction in ERK1/2 phosphorylation at at 50 to 100 nM after 48 hrs by Western blot analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of TOPK in human A549 cells assessed as reduction in Histone H3 phosphorylation at Ser10 residue at 50 to 100 nM after 48 hrs by Western blot analysis
Inhibition of TOPK autophosphorylation at Thr9 residue in human A549 cells at 50 to 100 nM after 48 hrs by Western blot analysis
Inhibition of TOPK in human HCT116 cells assessed as reduction in ERK1/2 phosphorylation at at 50 to 100 nM after 48 hrs by Western blot analysis
Inhibition of TOPK in human HCT116 cells assessed as reduction in Histone H3 phosphorylation at Ser10 residue at 50 to 100 nM after 48 hrs by Western blot analysis
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