BioAssay by Target (List) for Gene (Select 5607) - PubChem BioAssay - NCBI

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Select item 19564881.

Inhibition of MEK5 (unknown origin) by discoverX kinomescan assay

Source:: ChEMBL

Protein Target:: Dual specificity mitogen-activated protein kinase kinase 5

Assay data:1 Tested

AID:: 1956488

Summary Related BioAssays by Target

Select item 19564812.

Inhibition of MEK5 (unknown origin)

Source:: ChEMBL

Protein Target:: Dual specificity mitogen-activated protein kinase kinase 5

Assay data:3 Tested

AID:: 1956481

Summary Related BioAssays by Target

Select item 19144893.

Selectivity interaction (KinomeScan (DiscoverX)) EUB0000294b MAP2K5

Source:: ChEMBL

Protein Target:: Dual specificity mitogen-activated protein kinase kinase 5

Assay data:1 Tested

AID:: 1914489

Summary Related BioAssays by Target

Select item 19141084.

Selectivity interaction (KinomeScan (DiscoverX)) EUB0000714a MAP2K5

Source:: ChEMBL

Protein Target:: Dual specificity mitogen-activated protein kinase kinase 5

Assay data:1 Tested

AID:: 1914108

Summary Related BioAssays by Target

Select item 19139335.

Selectivity interaction (KinomeScan (DiscoverX)) EUB0000701a MAP2K5

Source:: ChEMBL

Protein Target:: Dual specificity mitogen-activated protein kinase kinase 5

Assay data:1 Tested

AID:: 1913933

Summary Related BioAssays by Target

Select item 19139306.

Selectivity interaction (ScanMAX (DiscoverX)) EUB0000700a MAP2K5

Source:: ChEMBL

Protein Target:: Dual specificity mitogen-activated protein kinase kinase 5

Assay data:1 Tested

AID:: 1913930

Summary Related BioAssays by Target

Select item 19139117.

Selectivity interaction (NanoBRET assay (HEK293T cells)) EUB0000305b MAP2K5

Source:: ChEMBL

Protein Target:: Dual specificity mitogen-activated protein kinase kinase 5

Assay data:1 Tested

AID:: 1913911

Summary Related BioAssays by Target

Select item 19139108.

Selectivity interaction (KinomeScan (DiscoverX)) EUB0000305b MAP2K5

Source:: ChEMBL

Protein Target:: Dual specificity mitogen-activated protein kinase kinase 5

Assay data:1 Tested

AID:: 1913910

Summary Related BioAssays by Target

Select item 19139099.

Selectivity interaction (Enzymatic assay) EUB0000305b MAP2K5

Source:: ChEMBL

Protein Target:: Dual specificity mitogen-activated protein kinase kinase 5

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1913909

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 191388810.

Selectivity interaction (NanoBRET assay (HEK293T cells)) EUB0000321b MAP2K5

Source:: ChEMBL

Protein Target:: Dual specificity mitogen-activated protein kinase kinase 5

Assay data:1 Tested

AID:: 1913888

Summary Related BioAssays by Target

Select item 191388711.

Selectivity interaction (KinomeScan (DiscoverX)) EUB0000321b MAP2K5

Source:: ChEMBL

Protein Target:: Dual specificity mitogen-activated protein kinase kinase 5

Assay data:1 Tested

AID:: 1913887

Summary Related BioAssays by Target

Select item 191384112.

Selectivity interaction (KinomeScan (DiscoverX)) EUB0000698a MAP2K5

Source:: ChEMBL

Protein Target:: Dual specificity mitogen-activated protein kinase kinase 5

Assay data:1 Tested

AID:: 1913841

Summary Related BioAssays by Target

Select item 191355413.

Selectivity interaction (Quantitative chemical proteomics (cell-based phosphorylation and proliferation assays in Hs578t cells)) EUB0000147b MAP2K5

Source:: ChEMBL

Protein Target:: Dual specificity mitogen-activated protein kinase kinase 5

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1913554

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 191355314.

Selectivity interaction (KinomeScan (DiscoverX)) EUB0000147b MAP2K5

Source:: ChEMBL

Protein Target:: Dual specificity mitogen-activated protein kinase kinase 5

Assay data:1 Tested

AID:: 1913553

Summary Related BioAssays by Target

Select item 190954515.

Inhibition of MEK5 (unknown origin) expressed in baculovirus expression system incubated for 90 mins in presence of ATP by PKlight ATP detection reagent based luciferase assay

Source:: ChEMBL

Protein Target:: Dual specificity mitogen-activated protein kinase kinase 5

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1909545

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 190953516.

Binding affinity to wild type human partial length MEK5 (L98 to P448 residues) expressed in mammalian expression system by Kinomescan binding assay

Source:: ChEMBL

Protein Target:: Dual specificity mitogen-activated protein kinase kinase 5

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1909535

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 189355217.

Inhibition of human wild-type partial length MEK5 (L98 to P448 residues) expressed in mammalian expression system at 10 uM by Kinomescan method relative to control

Source:: ChEMBL

Protein Target:: Dual specificity mitogen-activated protein kinase kinase 5

Assay data:1 Tested

AID:: 1893552

Summary PubMed Citation Related BioAssays by Target

Select item 183546318.

MEK5 DiscoveRx kinase panel

Source:: ChEMBL

Protein Target:: Dual specificity mitogen-activated protein kinase kinase 5

Assay data:1 Tested

AID:: 1835463

Summary Related BioAssays by Target

Select item 183420819.

Inhibition of MEK5 (unknown origin) at 1 uM

Source:: ChEMBL

Protein Target:: Dual specificity mitogen-activated protein kinase kinase 5

Assay data:1 Tested

AID:: 1834208

Summary PubMed Citation Related BioAssays by Target

Select item 182379020.

Inhibition of recombinant human MAP2K5 using Ulight-ARTKQTARKSTGGKAPRKQLAGCG as substrate at 1 uM incubated for 120 mins in presence of ATP by LANCE method relative to control

Source:: ChEMBL

Protein Target:: Dual specificity mitogen-activated protein kinase kinase 5

Assay data:2 Tested

AID:: 1823790

Summary PubMed Citation Related BioAssays by Target

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Target

Proteins (1)
BioAssays with protein sequences specified as targets
RNAi Target, Active (7)
BioAssays with gene sequences specified as RNAi targets and the activity is active

BioActivity

Active Compounds (30)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (1)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (21)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Summary (1)
BioAssays summarizing information from multiple assays for validated chemical probes or small molecule leads
Confirmatory (30)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
Primary Screening (40)
Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose
Chemical Screens (123)
BioAssays reporting BioActivity of chemical reagents
RNAi Screens (43)
BioAssays reporting BioActivity of RNAi reagents

Assay Project (1)
BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

Depositor Category

Literature Extraction (99)
BioAssays extracted from the literature
NIH MLP (1)
BioAssays deposited by the NIH Molecular Libraries Program
Other (65)
BioAssays deposited by other experimentalists

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BioAssay by Target (List) for Gene (Select 5607) (166)
PubChem BioAssay
PREDICTED: Homo sapiens ADP ribosylation factor GTPase activating protein 1 (ARF...
PREDICTED: Homo sapiens ADP ribosylation factor GTPase activating protein 1 (ARFGAP1), transcript variant X8, mRNA
gi|2462580859|ref|XM_054323682.1|

Nucleotide

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