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Inhibition of KLK7 (unknown origin)
Assay data:2 Active, 2 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested
SummaryRelated BioAssays by Target
Inhibition of human recombinant kallikrein 7 (23 to 252 residues) using MCA-RPKPVE-Nval-WRK(Dnp)-NH2 as substrate by fluorescence based analysis relative to tutuilamide A
Assay data:1 Tested
Inhibition of human recombinant kallikrein 7 (23 to 252 residues) using MCA-RPKPVE-Nval-WRK(Dnp)-NH2 as substrate by fluorescence based analysis relative to gabexate mesylate
Inhibition of human recombinant kallikrein 7 (23 to 252 residues) using MCA-RPKPVE-Nval-WRK(Dnp)-NH2 as substrate by fluorescence based analysis
Assay data:2 Active, 2 Activity ≤ 1 µM, 3 Tested
Selectivity interaction (Serine protease panel) EUB0000735a KLK7
Inhibition of C-terminal poly-His-tagged human recombinant KLK7 (30 to 253 residues) transfected in CHO cells assessed as inhibition constant using KHLY-pNA as fluorogenic substrate incubated for 30 mins by fluorescence plate reader assay
Assay data:24 Active, 25 Activity ≤ 1 µM, 25 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Human KLK7 Fluorescence-Lifetime Assay from Article 10.1038/nchembio.2208: "Small-molecule factor D inhibitors targeting the alternative complement pathway."
Assay data:2 Active, 1 Activity ≤ 1 µM, 5 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Inhibition Assay from US Patent US9744148: "Kallikrein 7 inhibitors"
Assay data:89 Active, 50 Activity ≤ 1 µM, 90 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
KLK7 Assay from US Patent US9695194: "Benzoxazinone derivatives for treatment of skin diseases"
Assay data:18 Active, 17 Activity ≤ 1 µM, 18 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Inhibition of KLK7 (unknown origin) assessed as inhibition of release of AMC fluorescent product using H-VPR-AMC as substrate at 10 uM incubated for 30 mins by microplate reader relative to control
Assay data:7 Tested
SummaryPubMed CitationRelated BioAssays by Target
Covalent binding affinity to of N-terminal SUMO and His6-tagged human KLK7 expressed in Escherichia coli Rosetta (DE3) pLysS assessed as compound binding to His57 of catalytic triad by mass spectrometry
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of N-terminal SUMO and His6-tagged human KLK7 assessed as protease activity by measuring fluorogenic peptide substrate NFF-3 cleavage (Rvb = >400 pmol/(min.ug)
Assay data:3 Tested
Inhibition of N-terminal SUMO and His6-tagged human KLK7 assessed as reduction in vaspin-N-terminal cleavage using compound pre-treated KLK7 incubated for 60 mins by Coomassie-staining based SDS-PAGE method
Inhibition of N-terminal SUMO and His6-tagged human KLK7 expressed in Escherichia coli Rosetta (DE3) pLysS assessed as reduction in covalent KLK7-vaspin complex formation using compound pre-treated KLK7 incubated for 60 mins by Coomassie-staining based SDS-PAGE method
Assay data:3 Active, 3 Tested
Inhibition of recombinant human KLK7 using S-2586 substrate
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of recombinant human C-terminal 10-His-tagged KLK7 (Glu23 to His252 residues) expressed in mouse NS0 cells using 5-FAM-E-A-L-Y-L-V-S-G-C(5-TAMRA) as substrate incubated for 40 mins by FLINT assay
Assay data:15 Tested
Inhibition of recombinant C-terminal 10His-tagged human KLK7 (Glu23 to His252 residues) expressed in mouse NS0 cells using 5-FAM-E-A-L-Y-L-V-S-G-C as substrate after 40 mins by fluorescence intensity assay
Inhibition of recombinant human KLK7 expressed in Pichia pastoris X-33 using KHLY-pNA as substrate at pH 8 and 298 K measured every 60 secs for 600 secs
Assay data:6 Tested
Inhibition of thermolysin activated recombinant human C-terminal 10-His tagged KLK7 (E23 to H252 residues) using MOCAc-Arg-Pro-Lys-Pro-Val-Glu-Nva-Trp-Arg-Lys(Dnp)-NH2 as substrate preincubated for 10 mins followed by substrate addition and measured after 30 mins by fluorescence analysis
Assay data:10 Active, 2 Activity ≤ 1 µM, 21 Tested
Inhibition of recombinant human KLK7 expressed in expressed in Pichia pastoris X-33 cells at 5 uM using KHLY-pNA as susbtrate measured every 15 secs for 10 mins by colorimetric analysis relative to control
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