Warning: The NCBI web site requires JavaScript to function. more...
An official website of the United States government
The .gov means it's official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.
The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.
Inhibition of N-terminal 6xHis-SUMO tagged human HTRA1 catalytic PDZ domain (D161 to P480 residues) expressed in Escherichia coli BL21 (DE3) cells using Mca-Ile-Arg-Arg-Val-Ser-Tyr-Ser-Phe-Lys(Dnp)-Lys as substrate preincubated for 30 mins followed by substrate addition and measured after 2 hrs by fluorescence method
Assay data:205 Active, 17 Activity ≤ 1 nM, 205 Activity ≤ 1 µM, 205 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
HTRA1 Assay from US Patent US11377439: "Heterocyclic prolinamide derivatives"
Assay data:164 Active, 164 Activity ≤ 1 µM, 164 Tested
Biological Assay from US Patent US11267803: "Carbocyclic prolinamide derivatives"
Assay data:48 Active, 46 Activity ≤ 1 µM, 48 Tested
Chromogenic Enzyme Activity Assays from US Patent US11149067: "Tailored cyclodepsipeptides as potent non-covalent serine protease inhibitors"
Assay data:31 Active, 19 Activity ≤ 1 µM, 33 Tested
HtrA1 Enzyme Inhibition Assay from US Patent US11059858: "Difluoroketamide derivatives as HtrA1 inhibitors"
Assay data:60 Active, 29 Activity ≤ 1 nM, 60 Activity ≤ 1 µM, 60 Tested
Enzyme Inhibition Assay from US Patent US11014963: "Trifluoromethylpropanamide derivatives as HTRA1 inhibitors"
Assay data:202 Active, 17 Activity ≤ 1 nM, 202 Activity ≤ 1 µM, 202 Tested
Enzyme Inhibition Assay from US Patent US11001555: "Difluoroketamide derivatives as HTRA1 inhibitors"
Assay data:22 Active, 16 Activity ≤ 1 nM, 22 Activity ≤ 1 µM, 22 Tested
Enzyme Inhibition Assay from US Patent US10870623: "Trifluoromethylpropanamide derivatives as HTRA1 inhibitors"
Assay data:23 Active, 2 Activity ≤ 1 nM, 23 Activity ≤ 1 µM, 23 Tested
Enzyme Inhibition Assay from US Patent US10865182: "Difluoroketamide derivatives as HtrA1 inhibitors"
Assay data:17 Active, 7 Activity ≤ 1 nM, 17 Activity ≤ 1 µM, 17 Tested
Full Length HTRA1 Assay from US Patent US10730832: "Aliphatic prolinamide derivatives"
Assay data:130 Active, 128 Activity ≤ 1 µM, 130 Tested
Enzyme Inhibition Assay from US Patent US10428108: "Difluoroketamide derivatives"
Assay data:93 Active, 90 Activity ≤ 1 µM, 93 Tested
Enzyme Inhibition Assay from US Patent US9980929: "Trifluoromethylpropanamide derivatives"
Assay data:73 Active, 1 Activity ≤ 1 nM, 68 Activity ≤ 1 µM, 73 Tested
Inhibition of His-tagged L56/HtrA1 (140 to 480 residues) (unknown origin) expressed in TB1 Escherichia coli at 10 to 50 uM pre-incubated for 15 mins before FITC-labeled dephosphorylated casein substrate addition and measured every 5 mins for 30 mins by fluorescence assay
Assay data:1 Active, 1 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Inhibition of full length His-tagged human HTRA1 using Mca-H20PT as substrate preincubated for 10 mins followed by substrate addition and measured after 10 mins by spectrofluorometry
Inhibition of N-terminal 6xHis-SUMO tagged human HTRA1 catalytic and PDZ domain (D161 to P480 residues) expressed in Escherichia coli BL21 (DE3) cells using Mca-Ile-Arg-Arg-Val-Ser-Tyr-Ser-Phe-Lys(Dnp)-Lys as substrate preincubated for 30 mins followed by substrate addition and measured after 2 hrs by fluorescence method
Assay data:15 Active, 15 Activity ≤ 1 µM, 15 Tested
Inhibition of N-terminal 6xHis-SUMO tagged human HTRA1 catalytic-PDZ domain (D161 to P480 residues) expressed in Escherichia coli BL21 (DE3) cells using Mca-Ile-Arg-Arg-Val-Ser-Tyr-Ser-Phe-Lys(Dnp)-Lys as substrate preincubated for 30 mins followed by substrate addition and measured after 2 hrs by fluorescence method
Assay data:61 Active, 29 Activity ≤ 1 nM, 61 Activity ≤ 1 µM, 61 Tested
Genes that modify the natural suppressive ability of myoepithelial cells: 3D co-culture siRNA screen
Assay data:18 Active, 83 Tested
Summary
Filters: Manage Filters
Your browsing activity is empty.
Activity recording is turned off.
Turn recording back on