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Potency index, ratio of ixazomib IC50 to compound IC50 for inhibition of human 20S proteasome using Suc-LLVY-AMC as substrate measured every 5 mins for 120 mins by fluorescence based assay
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of chymotrypsin-like enzyme activity of purified human 20S proteasome using Suc-Leu-Leu-Val-Tyr-AMC as substrate at 1 ug/ml by fluorescence method
Assay data:33 Tested
Inhibition of chymotrypsin-like enzyme activity of purified human 20S proteasome using Suc-Leu-Leu-Val-Tyr-AMC as substrate by fluorescence method
Assay data:13 Active, 13 Activity ≤ 1 µM, 35 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of chymotrypsin-like of human 20S proteasome using chromophoric Suc-LLVY-AMC as substrate after 60 mins by fluorescence assay
Assay data:5 Active, 2 Activity ≤ 1 µM, 5 Tested
Identification of proteins required for the processing of the EWS-FLI1 nascent transcript
Assay data:59220 Tested
Summary
A screen to identify genes that regulate lymphatic endothelial cell migration - Primary Screen
Assay data:1034 Active, 18120 Tested
SummaryRelated BioAssays by Depositor
A screen to identify synthetic lethal interactions with E-cadherin in an MCF10A isogenic cell line
Assay data:2442 Active, 18052 Tested
SummaryPubMed Citation
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced TNF-alpha response in human macrophages_Primary screen TNF readout
Assay data:2853 Active, 18113 Tested
SummaryRelated BioAssays by Same Project
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced TNF-alpha response in human macrophages_Secondary screen TNF readout
Assay data:731 Active, 3462 Tested
Inhibition of 20S proteasome activity in human ANBL-6 cells
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Inhibition of human 26S proteasome using suc-LLVY-AMC as substrate up to 40 mins by fluorescence assay
Inhibition of human 20S proteasome using Suc-LLVY-AMC as substrate measured every 5 mins for 120 mins by fluorescence based assay
Assay data:5 Active, 5 Activity ≤ 1 µM, 5 Tested
Inhibition of 20S proteasome in human HeLa cells at 2xIC50 using LLVY-R110 peptide as substrate measured up to 36 hrs by fluorescence based assay
Assay data:2 Active, 2 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of 20S proteasome in human BE(2)-C cells at 2xIC50 using LLVY-R110 peptide as substrate measured up to 36 hrs by fluorescence based assay
Inhibition of chymotrypsin-like activity of 26S proteasome in intact human Karpas 1106p cells assessed as substrate hydrolysis using Suc-LLVY-(D)-aminoluciferin as substrate after 3 hrs by cell-based Proteasome-Glo assay
Assay data:1 Active, 2 Tested
Inhibition of 26S proteosome in human Hep3B cells grown under in hypoxic condition for 4 hrs assessed as downregulation of HIF1alpha level at 10 uM added together with cycloheximide and measured after up 45 mins post dose by Western blot analysis
Assay data:1 Tested
Inhibition of 26S proteosome in human Hep3B cells grown under in normoxic condition for 4 hrs assessed as downregulation of HIF1alpha level at 10 uM added together with cycloheximide and measured after up 45 mins post dose by Western blot analysis
Negative allosteric modulation of SDS-activated human erythrocytes 20S proteasome assessed as reduction in human alpha-synuclein degradation at 1 uM after 1 hr by SDS-PAGE analysis
Assay data:2 Active, 4 Tested
Negative allosteric modulation of SDS-activated human erythrocytes 20S proteasome assessed as reduction in human alpha-synuclein degradation at 10 uM after 1 hr by SDS-PAGE analysis
Assay data:7 Active, 7 Tested
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