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Enzyme Kinetic Assay from US Patent US9340574: "Inhibitors of protein tyrosine phosphatases"
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
PTP pNPP Assay from US Patent US9217012: "Inhibitors of protein tyrosine phosphatases"
Assay data:4 Active, 3 Activity ≤ 1 µM, 4 Tested
PTP Assay from Article 10.1002/cbic.200600287: "Cellular inhibition of protein tyrosine phosphatase 1B by uncharged thioxothiazolidinone derivatives."
Assay data:7 Active, 16 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of DUSP22 (unknown origin) pre-incubated for 20 mins followed by fluorescence substrate addition and measured after 120 mins by DiFMUP assay
Assay data:1 Active, 1 Tested
Inhibition of DUSP22 (unknown origin) assessed as change in enzyme activity at 150 uM using PNPP substrate incubated for 15 mins relative to control
Assay data:1 Tested
SummaryRelated BioAssays by Target
Inhibition of LMWPTP (unknown origin) using DiFMUP as substrate at 100 uM incubated for 30 mins followed by substrate addition at pH 6.5 by standard phosphatase assay based fluorescence analysis
Assay data:3 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of LMWPTP (unknown origin) using DiFMUP as substrate incubated for 30 mins followed by substrate addition at pH 6.5 by standard phosphatase assay based fluorescence analysis
Assay data:2 Tested
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
Inhibition of VHX (unknown origin) expressed in Escherichia coli using pNPP as substrate at 200 uM after 5 mins by spectrophotometry
Inhibition of GST-tagged MKPX (unknown origin) by plate reader analysis using DiFMUP as substrate
Inhibition of GST-tagged MKPX (unknown origin) at 10 uM by plate reader analysis using DiFMUP as substrate
Assay data:5 Tested
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced TNF-alpha response in human macrophages_Primary screen TNF readout
Assay data:2853 Active, 18113 Tested
SummaryRelated BioAssays by Same Project
Inhibition of recombinant VHX (unknown origin) using OMFP as substrate after 1 hr by fluorescence assay
A screen to identify synthetic lethal interactions with E-cadherin in an MCF10A isogenic cell line
Assay data:2442 Active, 18052 Tested
SummaryPubMed Citation
A screen to identify genes that regulate lymphatic endothelial cell migration - Primary Screen
Assay data:1034 Active, 18120 Tested
SummaryRelated BioAssays by Depositor
Identification of proteins required for the processing of the EWS-FLI1 nascent transcript
Assay data:59220 Tested
Inhibition of human GST-tagged full length MKPX assessed as DiFMUP hydrolysis at 10 uM by fluorometric kinetic-based assay
Assay data:6 Tested
Inhibition of human GST-tagged full length MKPX assessed as DiFMUP hydrolysis by fluorometric kinetic-based assay
A whole genome RNAi screen highlights components of the ER/Golgi as a prominent source of resistance to immunotoxin-mediated cytotoxicity
Assay data:555 Active, 64752 Tested
Inhibition of DUSP22 (unknown origin) using DiFMUP as substrate at 5 uM relative to control
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