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Modulation of ProLink-fused human CXCR7 expressed in CHOK1 cell membranes assessed as induction of EA-tagged beta-arrestin recruitment after 30 mins by chemiluminescence method
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Agonist activity at wild type CXCR7 (unknown origin) expressed in HEK293E cells co-transfected with receptor-eYFP construct and beta-arrestin2-Rluc assessed as induction of receptor-mediated beta-arrestin recruitment by BRET assay
Agonist activity at CXCR7 D179N mutant (unknown origin) expressed in HEK293E cells co-transfected with receptor-eYFP construct and beta-arrestin2-Rluc assessed as induction of receptor-mediated beta-arrestin recruitment by BRET assay
Assay data:2 Active, 2 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Agonist activity at CXCR7 S198R mutant (unknown origin) expressed in HEK293E cells co-transfected with receptor-eYFP construct and beta-arrestin2-Rluc assessed as induction of receptor-mediated beta-arrestin recruitment by BRET assay
Agonist activity at CXCR7 D275N mutant (unknown origin) expressed in HEK293E cells co-transfected with receptor-eYFP construct and beta-arrestin2-Rluc assessed as induction of receptor-mediated beta-arrestin recruitment by BRET assay
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
Inhibition of anti-CXCR7 APC-antibody binding to CXCR7 in human MCF7 cells up to 10 uM preincubated for 30 mins followed by antibody addition by FACS Canto II cytofluorometric analysis
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Human ACKR3 (Chemokine receptors)
Assay data:4 Active, 4 Tested
Agonist activity at human CXCR7 expressed in CHOK1 cells assessed as induction of beta-arrestin recruitment at 10 uM by chemiluminescence method
Agonist activity at human CXCR7 expressed in CHOK1 cells assessed as induction of beta-arrestin recruitment by chemiluminescence method
Assay data:3 Active, 7 Tested
Agonist activity at human CXCR7 expressed in CHOK1 cells assessed as induction of beta-arrestin recruitment at 20 uM by chemiluminescence method
Agonist activity at CXCR7 (unknown origin)
Antagonist activity at CXCR7 (unknown origin)
Displacement of [125I]-CXCL12 from human CXCR7 expressed in CHOK1 cell membranes after 2 hrs by scintillation counting method
Assay data:27 Active, 24 Activity ≤ 1 µM, 27 Tested
Agonist activity at CXCR7 (unknown origin) expressed in HEK293E cells co-transfected with receptor-eYFP construct and beta-arrestin2-Rluc assessed as induction of receptor-mediated beta-arrestin recruitment by BRET assay
Assay data:4 Active, 3 Activity ≤ 1 µM, 4 Tested
Inhibition of anti-CXCR7 APC antibody clone 11G8 binding to CXCR7 in human MCF7 cells at 0.01 to 10 uM preincubated for 30 mins followed by anti-CXCR7 APC antibody clone 11G8 addition measured after 30 mins by flow cytometric method
Displacement of [125I]SDF-1alpha from ACKR3 (unknown origin) expressed in CHO cells after 1 hr by scintillation counting method
Assay data:54 Active, 18 Activity ≤ 1 µM, 55 Tested
Displacement of [125I]SDF-1alpha from ACKR3 (unknown origin) expressed in CHO cells at 30 uM after 1 hr by scintillation counting method
Assay data:5 Tested
Activation of YFP-tagged ACKR3 (unknown origin) expressed in HEK293E cells assessed as induction of Rluc-tagged beta-arrestin-2 recruitment after 30 mins by BRET assay
Activation of YFP-tagged ACKR3 D179N mutant (unknown origin) expressed in HEK293E cells assessed as induction of Rluc-tagged beta-arrestin-2 recruitment after 30 mins by BRET assay
Activation of YFP-tagged ACKR3 S198R mutant (unknown origin) expressed in HEK293E cells assessed as induction of Rluc-tagged beta-arrestin-2 recruitment after 30 mins by BRET assay
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