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hABHD6 Endocannabinoid related and lipase panel
Assay data:1 Tested
SummaryRelated BioAssays by Target
Inhibition of ABHD6 (unknown origin)
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of human ABHD6 expressed in HEK293T cells assessed as inhibition constant using 2-AG as substrate incubated for 30 mins by fluorescence plate reader assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of human ABHD6 expressed in HEK293 cells using TAMRA-FP as substrate by SDS-PAGE gel based competitive ABPP assay
Inhibition of human recombinant ABHD6
Assay data:5 Active, 5 Activity ≤ 1 µM, 5 Tested
Inhibition of human ABHD6 expressed in HEK293 cells using 1-AG as substrate incubated for 90 mins by sensitive fluorescence glycerol assay
Inhibition of human recombinant ABHD6 expressed in COS-7 cells in presence of FP-rhodamine labeled probe by SDS-PAGE based gel fluorescence scanning analysis
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Evaluation of ABHD6 Enzyme Inhibitory Activity Assay from US Patent US20240010658: "ABHD6 ANTAGONIST"
Assay data:20 Active, 14 Activity ≤ 1 nM, 20 Activity ≤ 1 µM, 20 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Fluorescent Assay from US Patent US10662159: "ABHD6 and dual ABHD6/MGL inhibitors and their uses"
Assay data:50 Active, 60 Activity ≤ 1 µM, 60 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Inhibition of human ABHD6 transfected in HEK293 cells using 2-OG as substrate preincubated for 30 mins followed by substrate addition measured after 5 mins by liquid scintillation spectroscopy
Assay data:3 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of human ABHD6 expressed in Expi293 cells using p-nitrophenyl acetate as substrate incubated for 30 mins by spectrophotometry
Inhibition of human ABHD6 expressed in HEK293 cells using [3H]2-OG as substrate at 10 uM preincubated for 30 mins followed by substrate addition and measured after 5 mins by liquid scintillation spectroscopy
Assay data:4 Tested
Inhibition of human ABHD6 expressed in HEK293 cells using [3H]2-OG as substrate preincubated for 30 mins followed by substrate addition and measured after 5 mins by liquid scintillation spectroscopy
Inhibition of human ABHD6 expressed in HEK293 cells using 2-OG as substrate preincubated for 30 mins followed by substrate addition and measured after 5 mins by liquid scintillation spectroscopy
Assay data:2 Active, 2 Activity ≤ 1 µM, 14 Tested
Inhibition of human ABHD6 expressed in HEK293 cell homogenates at 10 uM pre-incubated for 30 mins in presence of [1,2,3-3H]2-OG by liquid scintillation spectroscopy
Inhibition of human ABHD6 expressed in HEK293 cell homogenates pre-incubated for 30 mins in presence of [1,2,3-3H]2-OG by liquid scintillation spectroscopy
Inhibition of human ABHD6 at >10 uM
Assay data:22 Tested
Inhibition of ABHD6 in human intact PC3 cells preincubated for 30 mins followed by JW912 addition after 30 mins by gel-based ABPP assay
Inhibition of ABHD6 derived from human PC3 cell lysates preincubated for 30 mins followed by JW912 addition after 30 mins by gel-based ABPP assay
Assay data:32 Active, 12 Activity ≤ 1 µM, 34 Tested
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
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