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Antagonist activity against human PTHR1 expressed in CHO-K1 cells assessed as reduction in PTH induced cAMP level incubated for 30 mins in presence of IBMX by cAMP assay
Assay data:14 Active, 14 Activity ≤ 1 µM, 15 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
PRESTO-Tango GPCRome screening (PTH1R)
Assay data:1 Tested
SummaryRelated BioAssays by Target
Antagonist activity at PTHR1 (unknown origin) expressed in CHOK1 cells co-expressing Gs/Gq assessed as reduction in human PTH (1 to 34 residues)-induced cAMP level incubated for 30 mins
Assay data:13 Active, 8 Activity ≤ 1 µM, 13 Tested
Antagonist activity at human PTHR1 expressed in CHOK1 cells co-expressing Gs/Gq assessed as reduction in human PTH (1 to 34 residues)-induced cAMP accumulation incubated for 30 mins by HTRF assay
Assay data:11 Active, 3 Activity ≤ 1 µM, 20 Tested
Agonist activity at PTH1 receptor (unknown origin) assessed as induction of cAMP
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
Intrinsic activity at human PTH receptor expressed in OK-1 cells assessed as increase in cAMP production
Assay data:4 Tested
SummaryPubMed CitationRelated BioAssays by Target
Partial agonist activity at human PTH receptor expressed in OK-1 cells assessed as increase in cAMP production
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
Binding affinity to human PTH receptor expressed in OK-1 cells
Agonist activity at recombinant human PTHR1 expressed in pig LLC-PK1 cells assessed as increase in cAMP production measured after 20 mins by EIA
Assay data:11 Active, 1 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 12 Tested
Activity at human PTH1 receptor at 10 uM
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
Agonist activity at human PTH1 receptor expressed in human GP2.3 cells assessed as induction of cAMP at 0.1 to 100 nM preincubated with protease activity quenched SIF followed by compound transfer to GP2.3 cells by luciferase reporter gene assay
Assay data:4 Active, 4 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Agonist activity at human PTH1 receptor expressed in human GP2.3 cells assessed as induction of cAMP at 0.1 to 100 nM preincubated with protease activity quenched SGF up to 4 hrs followed by compound transfer to GP2.3 cells by luciferase reporter gene assay
Agonist activity at human PTH1 receptor expressed in human GP2.3 cells assessed as induction of cAMP at 0.1 to 100 nM preincubated with simulated intestinal fluid for 45 mins followed by compound transfer to GP2.3 cells by luciferase reporter gene assay
Assay data:1 Active, 1 Tested
Agonist activity at human PTH1 receptor expressed in human GP2.3 cells assessed as induction of cAMP at 0.1 to 100 nM preincubated with simulated intestinal fluid for 20 mins followed by compound transfer to GP2.3 cells by luciferase reporter gene assay
Agonist activity at human PTH1 receptor expressed in human GP2.3 cells assessed as induction of cAMP at 0.1 to 100 nM preincubated with simulated intestinal fluid for 10 mins followed by compound transfer to GP2.3 cells by luciferase reporter gene assay
Agonist activity at human PTH1 receptor expressed in human GP2.3 cells assessed as induction of cAMP at 0.1 to 100 nM preincubated with simulated gastric fluid for 3 mins followed by compound transfer to GP2.3 cells by luciferase reporter gene assay
Assay data:1 Active, 2 Tested
Displacement of [125I]-PTH(1 to 34 residues) from R0 state of human PTHR1 expressed in African green monkey COS7 cell membranes incubated for >1 hr in presence of GTPgammaS by gamma radiation method
Assay data:7 Active, 7 Tested
Agonist activity at human PTH1 receptor expressed in human GP2.3 cells assessed as induction of cAMP at 0.1 to 100 nM preincubated with SIF for 10 mins followed by compound transfer to GP2.3 cells by luciferase reporter gene assay
Agonist activity at human PTH1 receptor expressed in human GP2.3 cells assessed as induction of cAMP at 0.1 to 100 nM preincubated with SGF for 2 mins followed by compound transfer to GP2.3 cells by luciferase reporter gene assay
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