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Reactivation of cyclosarin induced inhibition of BChE in human plasma assessed as first-order reactivation rate constant using ATCh as substrate incubated for 30 mins by Ellman's method
Assay data:4 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of human serum recombinant BChE using butyrylthiocholine iodide as a substrate at 10 uM incubated for 20 mins by DTNB reagent based Ellman's method
Assay data:9 Tested
Measurement of hBuChE Activity from Article 10.1021/jm801292b: "Tacripyrines, the first tacrine-dihydropyridine hybrids, as multitarget-directed ligands for the treatment of Alzheimer's disease."
Assay data:2 Active, 1 Activity ≤ 1 µM, 15 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Enzyme Inhibition Assay from Article 10.1021/jm060257t: "Discovery of huperzine A-tacrine hybrids as potent inhibitors of human cholinesterases targeting their midgorge recognition sites."
Assay data:6 Active, 1 Activity ≤ 1 nM, 6 Activity ≤ 1 µM, 6 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of human serum BuChE using butyrylthiocholine iodide as substrate preincubated with enzyme for 5 mins followed by substrate addition and measured after 5 mins by Ellman's method
Assay data:4 Active, 5 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of human BuchE using butyrylthiocholine iodide as substrate preincubated for 30 mins followed by substrate addition by Ellman's method
Assay data:17 Active, 8 Activity ≤ 1 µM, 50 Tested
Potency index, ratio of 6-chlorotacrine IC50 to test compound IC50 for recombinant human BChE
Assay data:23 Tested
Inhibition of BuChE (unknown origin)
Assay data:2 Active, 1 Activity ≤ 1 µM, 7 Tested
Inhibition of human recombinant BChE using butyrylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition and measured over 2 mins by UV-Vis spectrophotometric analysis based Ellman's method
Assay data:28 Active, 26 Activity ≤ 1 µM, 31 Tested
Inhibition of human plasma BuChE after 5 mins by spectrophotometric method
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Mixed-type inhibition of recombinant human serum BuChE at 0.5 to 2 nM using varying levels of butyrylthiocholine iodide as substrate pretreated for 5 mins followed by substrate addition measured for 5 mins by Lineweaver-Burk plot analysis
Assay data:1 Active, 1 Tested
Inhibition of human plasma BChE assessed as butyrylthiocholine hydrolysis preincubated for 10 mins followed by addition of substrate measured after 2 mins by spectrophotometric method
Assay data:4 Active, 2 Activity ≤ 1 µM, 11 Tested
Inhibition of human serum BuChE assessed as pseudo-first order rate constant for enzyme carbamoylation using butyrylthiocholine iodide as substrate preincubated for 2 to 30 mins followed by substrate addition by Ellman's method
Assay data:1 Tested
Ratio of galamthamine IC50 to compound IC50 for BuChE (unknown origin)
Inhibition of human serum BChE using butyrylthiocholine iodide as substrate by visible spectrophotometry
Assay data:4 Active, 8 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Inhibition of human BuChE using butyrylthiocholine as substrate by Ellman's method
Assay data:11 Active, 5 Activity ≤ 1 µM, 26 Tested
Inhibition of BuChE
Inhibition of human recombinant BChE
Assay data:15 Active, 13 Activity ≤ 1 µM, 15 Tested
Deactivation of human BchE F329S mutant assessed as residual enzyme activity at 2.1 uM after 15 mins
Inhibitory concentration against butyrylcholinesterase
Assay data:2 Tested
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