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CDK4/Cyclin D1 Mobility Shift Assay from US Patent US20230321042: "COMBINATION THERAPY"
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Biological Assay from US Patent US20230312583: "1H-IMIDAZO [4,5-H] QUINAZOLINE COMPOUND AS NOVEL SELECTIVE FLT3 INHIBITORS"
Assay data:21 Active, 11 Activity ≤ 1 nM, 21 Activity ≤ 1 µM, 21 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
CDK6/CyclinD1 Enzyme Reaction System from US Patent US20230303564: "PYRIMIDINE RING COMPOUND"
Assay data:13 Active, 4 Activity ≤ 1 nM, 13 Activity ≤ 1 µM, 13 Tested
CDK4/CyclinD1 Enzyme Reaction System from US Patent US20230303564: "PYRIMIDINE RING COMPOUND"
Assay data:12 Active, 3 Activity ≤ 1 nM, 12 Activity ≤ 1 µM, 12 Tested
CDK4/Cyclin D1 Mobility Shift Assay from US Patent US11718603: "CDK2 inhibitors"
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Enzyme Reaction System of CDK4/Cyclin D1 from US Patent US10626107: "Crystal form, salt type of substituted 2-hydro-pyrazole derivative and preparation method therefor"
Assay data:3 Active, 2 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 3 Tested
Enzyme Reaction System of CDK2/Cyclin A from US Patent US10626107: "Crystal form, salt type of substituted 2-hydro-pyrazole derivative and preparation method therefor"
Assay data:3 Active, 1 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 3 Tested
CDK6/CyclinD1 Enzymatic Activity Assay from US Patent US11685744: "CDK inhibitors and their use as pharmaceuticals"
Assay data:61 Active, 61 Activity ≤ 1 µM, 61 Tested
Enzymatic Activity Assay from US Patent US11685744: "CDK inhibitors and their use as pharmaceuticals"
Assay data:123 Active, 113 Activity ≤ 1 µM, 123 Tested
CDK2/CyclinA2 Enzymatic Activity Assay from US Patent US11673893: "CDK inhibitors and their use as pharmaceuticals"
Assay data:87 Active, 86 Activity ≤ 1 µM, 88 Tested
CDK Inhibition In Vitro Assay from US Patent US11643416: "Substituted 1′,2′-dihydro-3′H-spiro[cyclohexane-1,4′-pyrimido[5′,4′:4,5]pyrrolo[2,1-c][1,2,4]triazin]-3′-ones as cyclin-dependent kinase inhibitors"
Assay data:31 Active, 8 Activity ≤ 1 nM, 31 Activity ≤ 1 µM, 31 Tested
Inhibition of CDK6/cyclin D1 (unknown origin)
Assay data:12 Active, 9 Activity ≤ 1 µM, 14 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of CDK4/cyclin D1 (unknown origin)
Assay data:13 Active, 11 Activity ≤ 1 µM, 14 Tested
Assay data:2 Active, 1 Activity ≤ 1 µM, 3 Tested
Binding affinity to Cyclin D1 in human HepG2 cells by laser confocal microscopy
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of GST-tagged CDK2/cyclin D1 (unknown origin) expressed in Sf9 cells using RPPTLSPIPHIPR peptide as substrate in presence of ATP and [gamma33-P] ATP by radioisotope filter binding assay
Assay data:2 Active, 7 Activity ≤ 1 µM, 7 Tested
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of GST-tagged human CDK4/Cyclin D1 (unknown origin) expressed in baculovirus infected in Sf9 cells incubated for 30 mins in presence of [gamma-32P]ATP by radiometric scintillation counter method
Inhibition of CDK4/Cyclin D1 (unknown origin)
Assay data:31 Active, 8 Activity ≤ 1 nM, 31 Activity ≤ 1 µM, 32 Tested
Inhibition of N-terminus or C-terminus NLuc fused CDK6/Cyclin D1 (unknown origin) transfected in HEK293 cells by NanoBRET assay
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