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Inhibition of RNAase L in human A549 cells assessed as rRNA cleavage pretreated at 30 uM for 4 hrs followed by treated with 20 uM 2-5A by Western blotting analysis
Assay data:4 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of full length H-RNAase L expressed in Escherichia coli BL21 (DE3) assessed as inhibition rate incubated for 15 min in presence of 20 nM 2-5A for 15 mins by Coomassie staining based SDS-PAGE analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of full length H-RNAase L expressed in Escherichia coli BL21 (DE3) assessed as inhibition rate incubated for 15 min in presence of 5 nM 2-5A for 15 mins by Coomassie staining based SDS-PAGE analysis
Inhibition of full length H-RNAase L expressed in Escherichia coli BL21 (DE3) assessed as inhibition rate incubated for 15 min in presence of 1 nM 2-5A for 15 mins by Coomassie staining based SDS-PAGE analysis
Inhibition of recombinant full length H-RNAase L (1 to 741 residues) expressed in Escherichia coli BL21 (DE3) using 5'-FAM-UAA-UCA-AAU-UCU-UAU-UUG-CCC-CAU-UUU-UUU-GGU-UUA-BHQ-1-3' as substrate incubated for 60 min by FRET assay
Assay data:5 Active, 5 Tested
Inhibition of recombinant full length H-RNAase L (1 to 741 residues) expressed in Escherichia coli BL21 (DE3) assessed as inhibition rate in presence of 2-5A and ATP/MgCl2 by STD-NMR spectroscopy
Assay data:1 Active, 4 Tested
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
Induction of recombinant human RNase L activity expressed in Escherichia coli using F-5'-r(C11U2C7)-3' as substrate by polyacrylamide gel electrophoresis
Assay data:8 Active, 1 Activity ≤ 1 nM, 8 Activity ≤ 1 µM, 9 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Ratio of p5'A2'p5'A2'p5'A2'p5'A EC50 to compound EC50 for recombinant human RNase L activity
Assay data:7 Tested
Primary screen of kinases in signalling pathway between Protease activated receptor 2 (PAR2) and the ion channels Transient receptor potential vanilloid-4 (TRPV4) in HEK293 cells
Assay data:91 Active, 714 Tested
A screen to identify synergistic combinations in colorectal cancer - Primary Screen (SW620)
Assay data:15 Active, 794 Tested
SummaryPubMed CitationRelated BioAssays by Depositor
A screen to identify synergistic combinations in colorectal cancer - Primary Screen (SNUC5)
Assay data:11 Active, 794 Tested
A screen to identify synergistic combinations in colorectal cancer - Primary Screen (HCT15)
Assay data:18 Active, 794 Tested
A screen to identify synergistic combinations in colorectal cancer - Primary Screen (CAR1)
Assay data:9 Active, 794 Tested
A screen to identify synergistic combinations in colorectal cancer - Primary Screen (HT55)
Assay data:20 Active, 794 Tested
A screen to identify synergistic combinations in colorectal cancer - Primary Screen (RCM1)
Assay data:13 Active, 794 Tested
A screen to identify synergistic combinations in colorectal cancer - Primary Screen (HT29)
A screen to identify synergistic combinations in colorectal cancer - Primary Screen (SNUC1)
A screen to identify synergistic combinations in colorectal cancer - Primary Screen (LS513)
Assay data:16 Active, 794 Tested
A screen to identify synergistic combinations in colorectal cancer - Primary Screen (NCIH630)
Assay data:17 Active, 794 Tested
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